Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality
Abdelghafour, A., Younis, N., Hammad, S., Mohamed, H. (2021). Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality. EKB Journal Management System, 30(1), 1-16. doi: 10.21608/zjps.2021.60130.1018
Asmaa M Abdelghafour; Nahla N Younis; Sally K Hammad; Hoda E Mohamed. "Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality". EKB Journal Management System, 30, 1, 2021, 1-16. doi: 10.21608/zjps.2021.60130.1018
Abdelghafour, A., Younis, N., Hammad, S., Mohamed, H. (2021). 'Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality', EKB Journal Management System, 30(1), pp. 1-16. doi: 10.21608/zjps.2021.60130.1018
Abdelghafour, A., Younis, N., Hammad, S., Mohamed, H. Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality. EKB Journal Management System, 2021; 30(1): 1-16. doi: 10.21608/zjps.2021.60130.1018

Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality

Zagazig Journal of Pharmaceutical Sciences
Article 1, Volume 30, Issue 1, June 2021, Page 1-16  XML PDF (595.15 K)
Document Type: Review Articles
DOI: 10.21608/zjps.2021.60130.1018
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Authors
Asmaa M Abdelghafour1; Nahla N Younisorcid 2; Sally K Hammadorcid 3; Hoda E Mohamed email orcid 4
1Biochemistry department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Biochemistry department, Faculty of Pharmacy, Zagazig university, Zagazig, Egypt
3Biochemistry department, Faculty of Pharmacy, Zagazig University, Egypt
4Department of Bichemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
Abstract
Wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway is an evolutionarily conserved signaling which is not only important for regulation of embryogenesis and organ development, but also for injury repair, homeostasis and tissue remodeling. Dysregulation of this pathway either by upregulation or even downregulation is highly implicated in various diseases such as; liver diseases, kidney diseases, lung fibrosis, heart failure, vascular calcification, osteoporosis, cellular senescence, neurodegeneration, Alzheimer's disease and cancers. Thus, targeting Wnt/β-catenin signaling has attracted scientific research as a good strategy ameliorating several diseases.  In this review we discussed Wnt/β-catenin components, the Wnt-on state and the Wnt-off state. Furthermore, we summarized the effects of Wnt/β-catenin signaling in several distinct organs including brain, bone, liver, heart, lung and kidney. We also discussed various molecules that act as modulators of Wnt/β-catenin signaling pathway via targeting its components (Wnt, Frizzled, LRP5/6, Porcupine, Disheveled, β-catenin destruction complex and β-catenin activity) aiming to show their possible therapeutic potential in several diseases.
Keywords
Canonical Wnt signaling; klotho; casein kinase 1α; Frizzled; Disheveled
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