Effect of Letrozole versus Clomiphene Citrate on Endometrial Receptivity and Peri follicular Vascularity in Infertile Women with Polycystic Ovarian Syndrome
ELOSS, A., El Saied, A., Abd Elhameid, A., Mahdy, E. (2023). Effect of Letrozole versus Clomiphene Citrate on Endometrial Receptivity and Peri follicular Vascularity in Infertile Women with Polycystic Ovarian Syndrome. EKB Journal Management System, 29(1), 28-35. doi: 10.21608/zumj.2021.59551.2117
ASMAA ABDELHADY ELOSS; Amal Abdelaziz El Saied; Azza Abd Elmageid Abd Elhameid; Entesar Roshdy Mahdy. "Effect of Letrozole versus Clomiphene Citrate on Endometrial Receptivity and Peri follicular Vascularity in Infertile Women with Polycystic Ovarian Syndrome". EKB Journal Management System, 29, 1, 2023, 28-35. doi: 10.21608/zumj.2021.59551.2117
ELOSS, A., El Saied, A., Abd Elhameid, A., Mahdy, E. (2023). 'Effect of Letrozole versus Clomiphene Citrate on Endometrial Receptivity and Peri follicular Vascularity in Infertile Women with Polycystic Ovarian Syndrome', EKB Journal Management System, 29(1), pp. 28-35. doi: 10.21608/zumj.2021.59551.2117
ELOSS, A., El Saied, A., Abd Elhameid, A., Mahdy, E. Effect of Letrozole versus Clomiphene Citrate on Endometrial Receptivity and Peri follicular Vascularity in Infertile Women with Polycystic Ovarian Syndrome. EKB Journal Management System, 2023; 29(1): 28-35. doi: 10.21608/zumj.2021.59551.2117

Effect of Letrozole versus Clomiphene Citrate on Endometrial Receptivity and Peri follicular Vascularity in Infertile Women with Polycystic Ovarian Syndrome

Zagazig University Medical Journal
Article 5, Volume 29, Issue 1, January 2023, Page 28-35  XML PDF (596.67 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.59551.2117
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Authors
ASMAA ABDELHADY ELOSS email 1; Amal Abdelaziz El Saied2; Azza Abd Elmageid Abd Elhameid3; Entesar Roshdy Mahdy3
1OBSTETRIC & GYNECOLOGY DEPARTMENT FACULTY OF MEDICINE ZAGAZIG UNIVERSITY
2Professor of Obstetrics and Gynaecology, Faculty of Medicine - Zagazig University
3obstetric& gynecology departement faculty of medicin zagazig university
Abstract
Background: Polycystic ovarian syndrome is the most common endocrine problem in females with an incidence of (6 -10%) . The purpose of this study was to make acomparison between the effect of clomiphene citrate versus letrozole on the endometrial receptivity and perifollicular vascularity among infertile patients having PCOS. Methods: This randomized comparative clinical study was conducted in infertility clinic of laparoscopy&cytogenic unit, Obstetrics and Gynecology department , zagazig university , Egypt from June 2019 to June 2020. It included a total of 54 infertile women diagnosed as having PCOS, 27 women received Clomiphene Citrate 100 mg and 27 patients received letrozole 5mg for ovulation induction. Thickness and pattern of the endometrium , uterine and spiral artery Doppler indices were calculated for 3 subsequent cycles on HCG injection day. Either clomiphene citrate or Letrozole was administrated by mouth for 5 days from day 3 of menstrual cycle . Results: As regards peri follicular vascularity, highly valuable difference was detected between two groups tested on HCG injection day in the 3 subsequent cycles . Ovulation rates were higher in the letrozole group than in the Clomiphene citrate group, but the discrepancy was not statistically valuable , in letrozole (70%, 74%, 81%) and in clomiphene citrate (63.0%, 67%, 77%) in 3 subsequent cycles. Conclusions: Both Clomiphene citrate and letrozole increase perifollicular blood flow with significant difference in favour to letrozole, in letrozole group most of follicles were (grade3) and in Clomiphene citrate group (grade2) .
Keywords
Polycystic ovary syndrome (PCOS); clomiphene citrate; letrozole
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