Prospective Comparative Study between Silodosin 8 mg Versus Combination of Tadalafil 5mg and Silodosin 4mgfor treatment of Lower Urinary Tract Symptoms related to Benign Prostatic Hyperplasia | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 57, Volume 6, Issue 1, January 2023, Page 578-583 PDF (313.04 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2021.66651.1116 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mostafa AbdelRazek; Ahmad Abolyosr; Omar Mohammed; Atef Fathy; Mohammed Talaat  ; Ahmed M. Hassan
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| Urology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||||
| Abstract | ||||
| Background:In men, lower urinary tract symptoms (LUTS) are associated with benign prostatichyperplasia (BPH). Therapeutic options aim to relax prostate smooth muscle and/or reduce prostate enlargement. Objectives:To evaluate the efficacy of Silodosin 8 mgalone versus the combinationof Tadalafil 5mg and Silodosin 4 mgfor treatment of LUTS related to BPH. Patients and methods: About 203 patients with LUTS of BPH who completed the study up protocolpresented to our department classified into two groups group A (101 patients) received Silodosin 8 mg, group B (102 patients) received the combination of Tadalafil 5mg and Silodosin 4 mg. All results recorded and analyzed with Statistical Package for Social Science® (SPSS) and Microsoft Excel 2010. Results: The IPSS, QOL, IIEF score, Q-max and PVR showed significantly greater improvement in the combination of Tadalafil 5mg with Silodosin 4mg than monotherapy of Silodosin 8mg. Conclusions:Despite Silodosin 8mg is well-tolerated and effective treatment option in men with LUTS of BPH, butthe combination of tadalafil 5m and Silodosin 4mg is more effective and feasible for these patients. | ||||
| Keywords | ||||
| LUTS of BPH; Tadalafil 5mg; Silodosin 4mg; Silodosin 8mg | ||||
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