Effects of Anti-Tuberculous Drugs on Liver Function Profile in Libyan Patients with Tuberculosis | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 27, Volume 52, Issue 1, July 2013, Pages 740-751 PDF (610.09 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0000611 | ||
| Authors | ||
| Mokhtar Hadida* 1; Amal Abo-Smhadana2; Marwan Draid3 | ||
| 1Department of Family & Community Medicine, Faculty of Medicine, Tripoli University, 13662 Tripoli – Libya | ||
| 2Division of Zoology, Department of Biological Sciences, School of Basic Sciences, Academy of Graduate Studies, 72331, Janzour, Libya | ||
| 3Department of Pharmacology, Toxicology & Forensic Medicine, Faculty of Veterinary Medicine, Tripoli University, 13662 Tripoli, Libya. | ||
| Abstract | ||
| The present prospective study was designed to conduct a local survey on patients under anti-tuberculosis therapy hospitalized in Abo-Seta hospital, Tripoli, Libya from the safety point of view. The study was carried out on 75 inpatients. The effects of the used drugs on some hematological parameters and liver function biomarkers were monitored for six-month period of treatment. Our survey showed that tuberculosis affects people with low and medium levels of education and withno job. The frequency of adverse effects related to treatment with Abo-Seta hospital regimen were decreases in WBCs count (-38.7%), RBCs count (-32.1%), platelets count (-33%) and hemoglobin concentration (-35.5%). However, in most of the cases, it was not necessary to modify the treatment regimen because of such side effects. Some parameters showed spontaneous recovery as RBCs count (+22.1%) and hemoglobin level (+20.1%). Combined therapy of ethambutol, isoniazid, pyrazinamide, and rifampicin has been used in Abo-Seta hospital, as a regimen for tuberculosis infection, may be associated with a high risk of hepatic toxicity during first month of treatment. However, during the remaining five months there was a good recovery of liver enzymes profile. Upon the data obtained from the present study, it could be concluded that TB patient after 6 month of treatment didn't develop multi-drug resistant tuberculosis (MDR-TB) | ||
| Keywords | ||
| tuberculosis; Anti-tuberculosis therapy; safety profile | ||
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