Evaluation Of Curcumin And Chitosan Protective Effect On Submandibular Salivary Gland Toxicity Induced By Monosodium Glutamate In Male Albino Rats | ||||
| Egyptian Dental Journal | ||||
| Article 1, Volume 67, Issue 2 - Serial Number 3, April 2021, Page 1187-1197 PDF (6.11 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2021.55176.1426 | ||||
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| Author | ||||
asmaa elgamal  
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| Lecturer, Oral Biology Department, Faculty of Dentistry, Beni-Suef University, Egypt. | ||||
| Abstract | ||||
| ABSTRACT Monosodium glutamate is a well-known food flavor additives that is widely used all over the world but its chronic intake leads to many reported side effects. Aim of the study: The goal of this study was to evaluate the prophylactic role of chitosan and curcumine extract, as a well-known antioxidant, against the submandibular salivary gland (SMG) damage induced by chronic intake of monosodium glutamate (MSG). Material and methods: 36 adult male Albino rats were randomly divided into 4 groups; Group 1 (control) group, group2 (MSG group): rats received a daily dose of MSG only by oral gavage, group 3 ( MSG + Chitosan treated group): rats received a daily dose of MSG + chitosan and finally group 4 ( MSG + curcumin treated group): rats received a daily dose of MSG + curcumin. After 6 weeks, the submandibular salivary glands were excised and processed for histological and caspase 3 immunohistochemical examination. Results: histological examination by H&E stain of group 3 and 4 revealed improvement of secretory portion architecture in addition to decreased vaculation and pleomorphism than group 2. There were a high statistical significant difference, of caspase 3 immuno-expression, between the treated chitosan and curcumin groups (group3 and 4) and MSG group (group 2) as p values were 0.005 and 0.017 respectively. Conclusion: administration of chitosan or curcumin has a protective effect on SMG toxicity induced by chronic intake of MSG. | ||||
| Keywords | ||||
| Key words: monosodium glutamate toxicity; curcumin extract; chitosan; submandibular salivary gland | ||||
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