“Release characterization and biological effect of Glass Ionomer Functionalized with Two Different Chlorohexidine Derivatives”: "An in Vitro Study" | ||
| Egyptian Dental Journal | ||
| Article 4, Volume 67, Issue 2 - Serial Number 4, April 2021, Pages 1371-1383 PDF (1.24 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2021.55450.1430 | ||
| Authors | ||
| shaimaa abdallah* 1; Mohamed kandil2; Dina El Rafie3 | ||
| 1BDS, Researcher at biomaterial , Department of Biomaterials, Faculty of Dentistry, Ain- Shams University, organization of African unity St, El-Qobba Bridge, Al Waili, Cairo Governorate, Egypt | ||
| 2Lecturer of Dental Biomaterials, Department of Biomaterials, Faculty of Dentistry, Ain- Shams University, organization of African unity St, El-Qobba Bridge, Al Waili, Cairo Governorate, Egypt. | ||
| 3Associate professor of Dental Biomaterials, Biomaterials Department, , Faculty of Dentistry, Ain- Shams University, organization of African unity St, El-Qobba Bridge, Al Waili, Cairo Governorate, Egypt. | ||
| Abstract | ||
| Abstract Aims: To evaluate the effect of adding two different chlorohexidine derivatives; chlorhexidine hexametaphosphate and chlorhexidine digluconate to glass ionomer at three different concentrations (0.25%, 0.75%and 1.5%) regarding the antibacterial effect, chlorhexidine release and fluoride release. Methods: A total of 405 specimens were prepared and tested after 7 days, 3 months and 6 months of storage in distilled water (n=5).For testing antibacterial effect, chlorhexidine release and fluoride release, the mix was packed in a ready-made Split Teflon molds to obtain disc-shaped specimen with dimensions 10 mm in diameter and 2 mm thickness according to ISO standardizations. One-way ANOVA and One-way repeated measure ANOVA test were used for statistical analysis of data. Results: The incorporation of chlorhexidine into ChemFil Superior glass ionomer cement in both derivatives has high significance ability to provide a long-term antimicrobial effect on Streptococcus mutans and Lactobacillius acidophilus. The chlorhexidine release was increased by adding chlorhexidine in both derivatives to GIC than the unmodified Glass-ionomer cement for study duration. However, the fluoride release was decreased in the modified specimens than the original one. Conclusions: addition of chlorhexidine enhanced the antibacterial effect of the glass ionomer and chlorhexidine release. However, fluoride release was reduced than original | ||
| Keywords | ||
| superior chemifil glass ionomer cement; chlorhexidine hexametaphosphate; chlorhexidine digluconate; antibacterial effect fluoride release | ||
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