Relationship between Epithelial MembraneProtein2 expression and Epstein Barr Virus, Cytomegalovirus and Herpes Simplex Virus infections in Nasopharyngeal Carcinoma. | ||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||
| Article 12, Volume 6, Issue 2, December 2014, Pages 101-105 PDF (304.47 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsc.2014.16036 | ||
| Authors | ||
| Mohammed Siddig Abd El Aziz1; Rania Saad Abdul Gader Suliman1; Hussain Gadelkarim Ahmed2 | ||
| 1Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Sudan University For Science and Technology, Sudan | ||
| 2Department of Pathology, College of Medicine, University of Hail, Kingdom of Saudi Arabia (KSA). | ||
| Abstract | ||
| Background: Lack of expression of Epithelial Membrane Protein-2(EMP2) in Nasopharyngeal carcinoma (NPC) is associated with adverse prognosticators and might confer tumor aggressiveness through hampering its interaction with specific membrane protein; and as Human Herpes Viruses linked to etiology of NPC, the aim of this study was to find out the relationship between EME2and these viruses. Methodology: In this study patients with NPC were investigated retrospectively. EMP2 expression was demonstrated by immunohistochemistry using n EMP2 antibody. EBV, CMV and HSV were identified by polymerase chain Reaction (PCR). Results: loss of EMP2 (negative) was identified in 10/92 (10.9%), P < 0.04; 10/53 (18.9%), P <0.05 and 4/18(22.2%), P<0.001 of EBV, CMV and HSV, respectively. Conclusion: In NPC, there is significant correlation between loss of expression of EMP2 and human herpes virtues (EBV, CMV and HSV). | ||
| Keywords | ||
| EMP2; EBV; CMV; HSV; Nasopharyngeal carcinoma | ||
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