Association of 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene polymorphism with Type 2 Diabetes Mellitus in a sample Egyptian Population
Elhalawany, S., Botros, ,., Hendawy, L., Fahmy, E., Younis, A. (2021). Association of 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene polymorphism with Type 2 Diabetes Mellitus in a sample Egyptian Population. EKB Journal Management System, 83(1), 1050-1055. doi: 10.21608/ejhm.2021.160614
Salah Hussein Elhalawany; , Raef Malak Botros; Laila Mahmoud Ali Hendawy; Eman Mohamed Eman Mohamed Fahmy; Alaa Tarek Younis. "Association of 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene polymorphism with Type 2 Diabetes Mellitus in a sample Egyptian Population". EKB Journal Management System, 83, 1, 2021, 1050-1055. doi: 10.21608/ejhm.2021.160614
Elhalawany, S., Botros, ,., Hendawy, L., Fahmy, E., Younis, A. (2021). 'Association of 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene polymorphism with Type 2 Diabetes Mellitus in a sample Egyptian Population', EKB Journal Management System, 83(1), pp. 1050-1055. doi: 10.21608/ejhm.2021.160614
Elhalawany, S., Botros, ,., Hendawy, L., Fahmy, E., Younis, A. Association of 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene polymorphism with Type 2 Diabetes Mellitus in a sample Egyptian Population. EKB Journal Management System, 2021; 83(1): 1050-1055. doi: 10.21608/ejhm.2021.160614

Association of 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene polymorphism with Type 2 Diabetes Mellitus in a sample Egyptian Population

The Egyptian Journal of Hospital Medicine
Article 38, Volume 83, Issue 1, April 2021, Page 1050-1055  XML PDF (410.9 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.160614
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Authors
Salah Hussein Elhalawany1; , Raef Malak Botros1; Laila Mahmoud Ali Hendawy1; Eman Mohamed Eman Mohamed Fahmy2; Alaa Tarek Younis2
1Department of internal Medicine, Endocrinology and Diabetes Unit,
2Department of of Internal Medicine, Endocrinology and Diabetes Unit,
Abstract
Background: Recently, numerous studies have associated polymorphisms in 11beta-hydroxysteroid dehydrogenase type 1 (HSD11β1) gene and T2DM risk. However, there is still a lack in the published literature evaluating the association between HSD11β1gene polymorphism and the risk of T2DM.
Objective: The Aim of the study was to assess the association of HSD11β1gene polymorphism (rs846910) with Type 2 diabetes mellitus (T2DM) in a sample of the Egyptian population.
Patients and methods: Our study was conducted on 100 subjects; their mean age was 50.26 ± 9.1 years old. They were selected from Diabetes Outpatient Clinics of our institution for 6 months in the period from June 2019 to December 2019. They were divided into two groups: 60 type 2 diabetic obese patients with BMI > 25 kg/m2 (Group I) and 40 age- and sex-matched controls (Group II).
Results: There was no statistically significant difference between cases and controls in terms of HSD11β1 polymorphism (rs846910). The regression analysis showed that the HSD11β1 polymorphism did not significantly increase the risk of diabetes mellitus (DM). Detection of HSD11β1 gene polymorphism in the study showed that homozygous GG genotype was more prevalent than GA genotype. However, there was no significant difference between GG and GA in terms of fasting and postprandial sugar and in terms of lipid profile.
Conclusion: The present study showed no significant association between HSD11β1 polymorphism (rs846910) and T2DM. Moreover, the HSD11β1polymorphism (rs846910) is not correlated with glycemic status or lipid profile.
 
Keywords
HSD11B1 gene polymorphism; Single nucleotide polymorphism; T2DM; Obese
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