The Frequency of Tumor Necrosis Factor-alpha Gene Polymorphism in Patients with Chronic Immune Thrombocytopenia. | ||
| Zagazig University Medical Journal | ||
| Article 19, Volume 29, Issue 1, January 2023, Pages 155-160 PDF (362.36 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2021.16776.1504 | ||
| Authors | ||
| nehal tarek elgohary* 1; usama roshdy elsafy2; marwa zakaria mohamed2; Nermin Raafat Abdel-Fattah3 | ||
| 1pediatric department faculty of medicine zagazig university | ||
| 2pediatric department,faculty of medicine,zagazig university | ||
| 3Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Background: The aim of this study was to reveal the frequency of Necrosis Factor _Alpha Gene Polymorphism in evaluation of severity and outcome of chronic immune thrombocytopenia in pediatric department of Zagazig University hospitals. Methods: We conduct a retrospective case control on 40 children diagnosed with chronic ITP and 40 age and sex healthy matched subjects as a control recruited from outpatient hematology clinic Faculty of Medicine, Zagazig University. Results: We found a highly significant difference between ITP group and control group as regarding TNF-α alleles where A allele was expressed in 43.7% of cases versus 17.5% 0f control, P value | ||
| Keywords | ||
| TNF_alpha; immune thrombocytopenia; PCR-ARMS | ||
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