Effect of a single dose of a bradykinin potentiating factor isolated from scorpion venom (Buthus occitanus) on total protein and albumin in serum of irradiated growing male Guinea pigs. | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 3, Volume 1, Issue 1, December 2009, Page 33-43 PDF (174.78 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2009.16303 | ||||
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| Author | ||||
| Muhammad M. A. Salman | ||||
| Zoology Department, Faculty of Science, South Valley Univesity, Qena, Egypt | ||||
| Abstract | ||||
| Whole body gamma irradiation of growing male Guinea pigs at the dose of 150 rads/animal reduced the levels of total protein and albumin. Growing Guinea pigs males (250 ± 30 gm. b. w.) were divided into two main groups; non-irradiated and irradiated groups and every main group were divided into four sub-groups. Irradiated growing Guinea pigs males groups were exposed to 150 Rads/animal by cesium-137 irradiation unit with a dose route of 1.06483 rad per second in a uniform manner and divided into four sub-groups. In irradiated groups; the first sub-groups were interaperitoneally (i.p) injected with100 µL saline solution. The second sub-groups were i.p. injection of bone marrow cells from their twins (2.5x106 cells/animall). The third sub-groups injected i. p with BPF (1µgm/gm. b. w.) which was dissolved in saline solution. The fourth sub-group injected with i.p solution of BPF (1µg/gm. b. w.) together with bone marrow cells from their twins (2.5x106 cells/animal). The non-irradiated sub-groups were injected with the same manner of irradiated sub-groups. The level of total protein and albumin in serum were measured at periods of 1, 3, 7, 14 and 21 days. Irradiated animals i.p. injection of BPF (single dose); appears slight to improve the changes which occurred in both total protein and albumin compared to irradiated sub-group. However, irradiated Guinea pigs injected with single dose of BPF together with bone marrow cells were more improvement of these parameters than sub-groups injected with only single dose of BPF. The improvement of these parameters may be attributed to stimulate growth factors and/or growth hormones to increase protein synthesis as an effect on the liver that necessitates future investigations. | ||||
| Keywords | ||||
| Irradiation; Bradykinin potentiting factor; Total protein; Albumin and Guinea pigs | ||||
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