Early onset gastric cancer in Egyptian patients: Is it really a different clinical entity?
Ramez, A., El-Zaafarany, M., Ghazy, H., Refky, B., Hassan, A., Hamed, M. (2021). Early onset gastric cancer in Egyptian patients: Is it really a different clinical entity?. EKB Journal Management System, 5(2), 173-180. doi: 10.21608/jcbr.2020.48678.1089
Ahmed M. Ramez; Maha El-Zaafarany; Hayam Ghazy; Basel Refky; Amany Hassan; Manar Hamed. "Early onset gastric cancer in Egyptian patients: Is it really a different clinical entity?". EKB Journal Management System, 5, 2, 2021, 173-180. doi: 10.21608/jcbr.2020.48678.1089
Ramez, A., El-Zaafarany, M., Ghazy, H., Refky, B., Hassan, A., Hamed, M. (2021). 'Early onset gastric cancer in Egyptian patients: Is it really a different clinical entity?', EKB Journal Management System, 5(2), pp. 173-180. doi: 10.21608/jcbr.2020.48678.1089
Ramez, A., El-Zaafarany, M., Ghazy, H., Refky, B., Hassan, A., Hamed, M. Early onset gastric cancer in Egyptian patients: Is it really a different clinical entity?. EKB Journal Management System, 2021; 5(2): 173-180. doi: 10.21608/jcbr.2020.48678.1089

Early onset gastric cancer in Egyptian patients: Is it really a different clinical entity?

Egyptian Journal of Cancer and Biomedical Research
Article 16, Volume 5, Issue 2, June 2021, Pages 173-180    PDF (2.42 M)
Document Type: Original Article
DOI: 10.21608/jcbr.2020.48678.1089
Authors
Ahmed M. Ramez* 1; Maha El-Zaafarany1; Hayam Ghazy1; Basel Refky2; Amany Hassan3; Manar Hamed1
1Medical Oncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2Surgical Oncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
3Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Abstract
Background: Little is known about characteristics of young patients with gastric carcinoma (GC) in Egypt. Aim: The purpose of this study was to define the clinicopathological features and survival of young GC patients in our population. Patients and Methods: We retrospectively analyzed data of 197 GC patients who were treated at our institution from 2011 to 2016. The clinicopathological characteristics and survival were compared between 61 young (≤45 years) and 136 older (>45 years) GC patients. We also studied variables impacting survival of younger patients. Results: The proportion of females, positive family history, and poorly differentiated tumors were significantly higher in young patients. Younger group showed significantly longer interval between symptoms and diagnosis (all P < 0.05). The mean overall survival (OS) of young patients was lower compared to older patients (10.7 vs. 18.7 months, respectively; P=0.06). Multivariate analyses revealed that distant metastasis and CA19-9 were independent factors for reduced survival in younger patients. Conclusion: We conclude that clinico-pathological characteristics of GC are different between young and old patients. Aggressive tumor biology and a significant diagnostic delay may have contributed to worse survival in younger patients.
Keywords
Gastric carcinoma; young age; clinicopathological features; prognosis
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