Effects of Allergic fungi on hematological and immunological parameters of human patients and rabbits | ||
| Egyptian Academic Journal of Biological Sciences, G. Microbiology | ||
| Article 6, Volume 6, Issue 2, December 2014, Pages 41-48 PDF (211.23 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsg.2014.16499 | ||
| Authors | ||
| Sanaa Huseein Mohamad1; Karkaz M. Thalij2; Khalil AL-Bander3; Batol Imran Dheeb4 | ||
| 1Biology Department, College of Science, Kirkuk University, Iraq | ||
| 2Food Science Department, College of Agriculture, Tikreet University, Iraq | ||
| 3Biology Department, College of Science, Tikreet University, Iraq | ||
| 4Biology Department, College of Science, Iraqia University, Iraq | ||
| Abstract | ||
| The hematological parameters and immunoglobulin levels were estimated in patients and healthy controls as well as experimentally infected lab animals. Rabbits were infected with fungi (A. niger, C. albicans, A. fumigatus, A. flavus, Fusarium spp, Alternaria spp). For 21 days before serum collection. Two hundred serum samples were collected from the respiratory tract infected patients and 20 samples from age and sex matched healthy persons. Hematological parameters in human and rabbits indicated high significance (p<0.001) of most blood parameters compared with control groups including leukocytosis; lymphocytosis; eosinophilia and increased ESR. ELISA testsshowed highly significant levels of IgE and IL4 (P≤0.001) in patients compared with the healthy people, and the highest increased were with the fungus Aspergillus fumigatus (450 IU /ml; 15pg / ml). Similarly, the levels of IgE and IgM in rabbits inhaled with fungi had significantly increased to 425 IU /ml, 390 mg/dl with Aspergillus fumigatus. | ||
| Keywords | ||
| hematological; Count; IgE; IgM; HIL-4 | ||
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