Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s Fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with Carisoprodol (Somadril Compound)
Abd El-Gawwad, H., Abd El-Azez, A. (2021). Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s Fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with Carisoprodol (Somadril Compound). EKB Journal Management System, 83(1), 1239-1249. doi: 10.21608/ejhm.2021.165171
Hanaa A. Abd El-Gawwad; Asmaa M. Abd El-Azez. "Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s Fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with Carisoprodol (Somadril Compound)". EKB Journal Management System, 83, 1, 2021, 1239-1249. doi: 10.21608/ejhm.2021.165171
Abd El-Gawwad, H., Abd El-Azez, A. (2021). 'Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s Fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with Carisoprodol (Somadril Compound)', EKB Journal Management System, 83(1), pp. 1239-1249. doi: 10.21608/ejhm.2021.165171
Abd El-Gawwad, H., Abd El-Azez, A. Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s Fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with Carisoprodol (Somadril Compound). EKB Journal Management System, 2021; 83(1): 1239-1249. doi: 10.21608/ejhm.2021.165171

Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s Fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with Carisoprodol (Somadril Compound)

The Egyptian Journal of Hospital Medicine
Article 68, Volume 83, Issue 1, April 2021, Page 1239-1249  XML PDF (828.6 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.165171
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Authors
Hanaa A. Abd El-Gawwad email ; Asmaa M. Abd El-Azez
Zoology Department, Faculty of Science, Al-Azhar University, Egypt
Abstract
Background: skeletal muscle relaxants contain a diverse mix of agents with different buildings and tools for achievement. These agents are classified as antispasmodics or antispasmodic agents, one of them is the drug carisoprodol.Objective: the current study aimed to investigate the possible effect of somadril compound on the skeletal muscle fibres and skin of fetuses maternally treated with carisoprodol.Material and methods: 30 pregnant female rats were categorized into 3 groups equal in number ten for each group, the first one (Control group ) ten pregnant female rats were administrated oral doses of distilled water; rats of the second group (S1) were administrated oral doses of carisoprodol in distilled water equivalent to 10.8 mg / 100 g body weight/ day and rats of the third group (S2) were administrated oral dose of carisoprodol in the distilled water equivalent to 21.6 mg /100g body weight/day. Rats of S1 and S2 were administrated oral dose of carisoprodol for 15 days from the 6th day to the 20th day of gestation. Many histological, histochemical and immunohistochemical studied were done to detect the alterations in the fetal skeletal muscles and skin. Results: fetal skin and skeletal muscle tissues of both treated groups showed many changes compared to the control group. Conclusion: treatment of the pregnant rats with carisoprodol led to numerous pathological changes in the fetal skin and skeletal muscle fibres.
 
Keywords
carisoprodol; fetuses; immunohistochemical; skin; histology; histochemical; skeletal musclefibres
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