Invasion and egress cascade in intracellular protozoa: Part 1 | ||
| Parasitologists United Journal | ||
| Article 1, Volume 14, Issue 1, April 2021, Pages 1-6 PDF (450.93 K) | ||
| Document Type: Editorial | ||
| DOI: 10.21608/puj.2021.67453.1110 | ||
| Abstract | ||
| A wide spectrum of pathogenic intracellular bacteria, viruses and protozoa adapt several strategies to enter into and exit from their host with optimum rates of survival, replication, and progression through life cycle stages as well as transmission. Egress is defined as the escape process from the host cell after replication and is followed by daughter cells exit. Therefore, egress is of fundamental importance for transmission processes, pathogen spread, and inflammation. Accordingly, molecules involved in egress mechanism(s) act as key factors in infection, pathogenesis, and transmission. They are considered as indirect virulence factors and potential drug targets. In fact, the egress cascade is a complex strategy involving several aspects, and its molecular analysis is difficult to investigate in vitro due to the contribution of several molecules in invasion or egress. It is impossible to independently investigate factors involved in egress from vacuolar and host cell membranes at the same time. The present editorial aims to simplify our knowledge regarding this critical issue with emphasis on its molecular tools and mechanisms | ||
| Keywords | ||
| apical secretory organelles; drug targets; egress; invasion; Plasmodium; protein kinases; Toxoplasma | ||
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