SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES
Abd El-Samii, Z., El-Feky, S., Osman, N. (2007). SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES. EKB Journal Management System, 16(1), 19-28. doi: 10.21608/zjps.2007.169370
Zakaria Abd El-Samii; Said El-Feky; Nermin Osman. "SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES". EKB Journal Management System, 16, 1, 2007, 19-28. doi: 10.21608/zjps.2007.169370
Abd El-Samii, Z., El-Feky, S., Osman, N. (2007). 'SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES', EKB Journal Management System, 16(1), pp. 19-28. doi: 10.21608/zjps.2007.169370
Abd El-Samii, Z., El-Feky, S., Osman, N. SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES. EKB Journal Management System, 2007; 16(1): 19-28. doi: 10.21608/zjps.2007.169370

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences
Article 3, Volume 16, Issue 1, June 2007, Pages 19-28    PDF (2.72 M)
Document Type: Original Article
DOI: 10.21608/zjps.2007.169370
Authors
Zakaria Abd El-Samii* ; Said El-Feky; Nermin Osman
Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Abstract
The key intermediate, 5-(p-chloropheny1)-1H-pyrazole-3-carboxylic acid hydrazide (3),was used for the synthesis of some new hydrazones 8a-g as well as some five membered heterocyclic derivatives such as pyrazoles 10, 11a,b, 12, pyrrole 13, 1,3,4-Oxadiazole 15, 1,2,4-triazole 17 and 1,3,4-thiadiazole 19. Identification of the new compounds was substantiated by spectral data and elemental analysis .Compound 6f which has a sulfadiazine moiety linked to the pyrazole showed a powerful anti-inflammatory activity than diclofenac sodium.
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