THE POTENTIAL ROLE OF THE ADRENAL MEDULLA IN HEMODYNAMIC RESPONSES DURING GABA ACTIVATION OF RAT AREA POSTREMA
Soliman, A. (2007). THE POTENTIAL ROLE OF THE ADRENAL MEDULLA IN HEMODYNAMIC RESPONSES DURING GABA ACTIVATION OF RAT AREA POSTREMA. EKB Journal Management System, 16(1), 37-42. doi: 10.21608/zjps.2007.169372
Adel Soliman. "THE POTENTIAL ROLE OF THE ADRENAL MEDULLA IN HEMODYNAMIC RESPONSES DURING GABA ACTIVATION OF RAT AREA POSTREMA". EKB Journal Management System, 16, 1, 2007, 37-42. doi: 10.21608/zjps.2007.169372
Soliman, A. (2007). 'THE POTENTIAL ROLE OF THE ADRENAL MEDULLA IN HEMODYNAMIC RESPONSES DURING GABA ACTIVATION OF RAT AREA POSTREMA', EKB Journal Management System, 16(1), pp. 37-42. doi: 10.21608/zjps.2007.169372
Soliman, A. THE POTENTIAL ROLE OF THE ADRENAL MEDULLA IN HEMODYNAMIC RESPONSES DURING GABA ACTIVATION OF RAT AREA POSTREMA. EKB Journal Management System, 2007; 16(1): 37-42. doi: 10.21608/zjps.2007.169372

THE POTENTIAL ROLE OF THE ADRENAL MEDULLA IN HEMODYNAMIC RESPONSES DURING GABA ACTIVATION OF RAT AREA POSTREMA

Zagazig Journal of Pharmaceutical Sciences
Article 5, Volume 16, Issue 1, June 2007, Page 37-42  XML PDF (1.84 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2007.169372
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Author
Adel Soliman email
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Abstract
The goal of this study was to investigate the potential role of the adrenal medulla in the multiple cardiovascular alterations that occur during activation of GABA(A) subtype in the area postrema. Blood pressure, heart rate, renal, iliac blood flows and plasma catecholamines were monitored during nonaliter infusion of muscimol (10 nl/min/10min, 1ng/nl) in the area postrema of the rats. Responses in pentobarbital-anesthetized male Albino rats, either intact (CON) or acutely adrenalectomized (ADX), were compared. Muscimol infusion increased mean arterial pressure in a dose-dependent manner in CON, but in ADX group such pressor effect was significantly attenuated. Heart rate was not significantly affected by drug infusion in either group. Renal bed actively constricted with non-significant transient increase in renal blood flow in both groups. Iliac blood flow increased markedly in CON, but remained unchanged in ADX. Iliac resistance was increased significantly in both CON and ADX, but it was rapidly attenuated to control values in CON. Plasma catecholamine concentrations was significantly elevated by muscimol infusion. We conclude that activation GABA(A) subtype may augment sympathetic outflow to the adrenals causing catecholamine release that in turn produces iliac bed vasodilation, but renal bed vasoconstriction. In ADX, this dominant effect of adrenal sympathetic activation was acutely attenuated because of withdrawal of sympathetic vasomotor tone in these resistance beds.
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