SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE
Said, M., Ghareb, N., El-Gendy, A. (2007). SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE. EKB Journal Management System, 16(2), 35-38. doi: 10.21608/zjps.2007.169387
Mohamed Said; Nagat Ghareb; Adel El-Gendy. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE". EKB Journal Management System, 16, 2, 2007, 35-38. doi: 10.21608/zjps.2007.169387
Said, M., Ghareb, N., El-Gendy, A. (2007). 'SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE', EKB Journal Management System, 16(2), pp. 35-38. doi: 10.21608/zjps.2007.169387
Said, M., Ghareb, N., El-Gendy, A. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE. EKB Journal Management System, 2007; 16(2): 35-38. doi: 10.21608/zjps.2007.169387

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE

Zagazig Journal of Pharmaceutical Sciences
Article 5, Volume 16, Issue 2, December 2007, Pages 35-38    PDF (1.15 M)
Document Type: Original Article
DOI: 10.21608/zjps.2007.169387
Authors
Mohamed Said* 1; Nagat Ghareb1; Adel El-Gendy2
1Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
2Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abstract
Condensation of 4-chlorophenylhydrazine (1) with ethyl  pyruvate led to the formation of ethy1 pyruvate 4- chlorophenyl thydrazone (2) Fischer Indolization of (2) gave ethyl 5-chloro-1H-indole-2-carboxylate (3). Vilsmeier-Hacck formylation of (3) gave ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate (4). The reaction of (4) with substituted anilines led to the formation of ethytl 3-(N-aryliminomethyl)-5-chloro-1H-indole-2-carboxylate (5-10). Structures of the new compounds were confirmed by both analytical and spectral data (IR, NMR and MS). Antimicrobial screening was also performed.
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