SYNTHESIS OF CERTAIN NOVEL PYRIDOTHIOPYRANOQUINOLINES AS POTENTIAL ANTICANCER AGENTS
El-Shemy, K., El-Badry, O., Roshdy, S., El-Enany, M., Ismail, M. (2006). SYNTHESIS OF CERTAIN NOVEL PYRIDOTHIOPYRANOQUINOLINES AS POTENTIAL ANTICANCER AGENTS. EKB Journal Management System, 15(2), 29-37. doi: 10.21608/zjps.2006.169424
Khaled El-Shemy; Osama El-Badry; Sameha Roshdy; Mervat El-Enany; Mohamed Ismail. "SYNTHESIS OF CERTAIN NOVEL PYRIDOTHIOPYRANOQUINOLINES AS POTENTIAL ANTICANCER AGENTS". EKB Journal Management System, 15, 2, 2006, 29-37. doi: 10.21608/zjps.2006.169424
El-Shemy, K., El-Badry, O., Roshdy, S., El-Enany, M., Ismail, M. (2006). 'SYNTHESIS OF CERTAIN NOVEL PYRIDOTHIOPYRANOQUINOLINES AS POTENTIAL ANTICANCER AGENTS', EKB Journal Management System, 15(2), pp. 29-37. doi: 10.21608/zjps.2006.169424
El-Shemy, K., El-Badry, O., Roshdy, S., El-Enany, M., Ismail, M. SYNTHESIS OF CERTAIN NOVEL PYRIDOTHIOPYRANOQUINOLINES AS POTENTIAL ANTICANCER AGENTS. EKB Journal Management System, 2006; 15(2): 29-37. doi: 10.21608/zjps.2006.169424

SYNTHESIS OF CERTAIN NOVEL PYRIDOTHIOPYRANOQUINOLINES AS POTENTIAL ANTICANCER AGENTS

Zagazig Journal of Pharmaceutical Sciences
Article 4, Volume 15, Issue 2, December 2006, Pages 29-37    PDF (2.2 M)
Document Type: Original Article
DOI: 10.21608/zjps.2006.169424
Authors
Khaled El-Shemy* 1; Osama El-Badry1; Sameha Roshdy1; Mervat El-Enany1; Mohamed Ismail2
1Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo
2Medicinal Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
Abstract
A series of ethyl 2-substituted aminopyrido [3',2': 5,6] thiopyrano [ 4,3,2-de] quinoline-1-carboxylate (VII)i-viii was obtained by reacting ethyl2-chloropyrido[3',2':5,6] thiopyrano [4,3,2-de] quinoline-1-carboxylate (VIa) with certain aromatic amines. Another series of ethyl 6-chloro-9,11-dimethyl-2-substituted aminopyrdo [3',2':5,6] thiopyrano [ 4,3,2-de] quinoline-1-carboxylate (VIIb)i-viii was also obtained by reacting ethyl 2,6-dichloro-9,11-dimethylpyrido [3',2':5,6] thiopyrano[4,3,2-de] quinoline-1-carboxylate  )VIb) with different amines. Molecular modeling study and in vitro cytotoxic effect of some samples of the synthesized compounds were also achieved.
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