Relationship between HCV infection and Insulin resistance in non-obese non- diabetic patients | ||
The Egyptian Journal of Hospital Medicine | ||
Article 8, Volume 41, Issue 1, October 2010, Pages 540-550 PDF (1.53 M) | ||
Document Type: Original Article | ||
DOI: 10.21608/ejhm.2010.16953 | ||
Authors | ||
Mostafa K. Mohamed1; Gamal Esmat2; Mohamed Said2; Mohamed Abdel Hamid3; Mohamed Hassany4; Mohamad A. Hassanein4; Kamal A. El- Atrebi4; Helmy El Gazzar5; M S. Omar6 | ||
1Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University. | ||
2Department of Tropical Medicine, Cairo University | ||
3Viral Hepatitis Research Laboratory, National Hepatology and Tropical Medicine Research Institute | ||
4Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute. | ||
5Department of Clinical pathology, Hearing and Speech Institute, Egypt. | ||
6Department of Clinical pathology, Faculty of Medicine, Bani Sewif University. | ||
Abstract | ||
Background:HepatitisCisamajorcauseofliver-relatedmorbidityandmortalityandrepresentsa majorpublichealthprobleminEgyptandworldwide.Thereisgrowingevidenceasregardtothe associationbetweenhepatitisCvirus(HCV)infectionandtype2diabetesmellitus.However,the mutuallinkandrelatedvirologicalimplicationhavenotbeenfullyclarified.Insulinresistance(IR) playsaprimaryroleinthedevelopmentoftype2DM.Thisissupportedbytheresultsofprospective longitudinalstudiesshowingthatIRisthebestpredictorofthedevelopmentoftype2DM,preceding itsonsetby10-20years. Aim:ToassessthecorrelationbetweenHCVmorbidityandInsulinresistance(IR)detectedby HOMAtestinnonediabeticnoneobeseHCVpatients Materials&Method:Thestudyparticipantsweresubcategorizedintotwogroups,Group(I): included867healthysubjects(negativeHCVRNA)asacontrolgroup.Group(II):included277 patientswithchronicHCVasastudygroup.The2groupsweresubjectedtothoroughhistorytaking, fullclinicalexamination,Anthropometricstudy,ultrasonographicexaminationandlaboratory investigationsincludingliverfunctions,viralmarkers,andqualitativePCRforHCVRNA,lipid profile,glucoseprofileandHOMAtest. Results:ThisstudyrevealedhigherinsulinresistanceintheHCVstudygroupthanthecontrolgroup. | ||
Keywords | ||
HCV-Insulinresistance; HOMA test | ||
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