Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC
EzzelArab, M., Hassanein, M., Hassany, M., Ahmad, S., AbdElBaki, A., AbdEl Moniem, N. (2018). Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC. EKB Journal Management System, 39(1), 208-217. doi: 10.21608/ejhm.2018.16964
MohamedA. EzzelArab; MohammadA. Hassanein; Mohamed Hassany; SalahEldeenM. Ahmad; AminM. AbdElBaki; NashwaA. AbdEl Moniem. "Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC". EKB Journal Management System, 39, 1, 2018, 208-217. doi: 10.21608/ejhm.2018.16964
EzzelArab, M., Hassanein, M., Hassany, M., Ahmad, S., AbdElBaki, A., AbdEl Moniem, N. (2018). 'Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC', EKB Journal Management System, 39(1), pp. 208-217. doi: 10.21608/ejhm.2018.16964
EzzelArab, M., Hassanein, M., Hassany, M., Ahmad, S., AbdElBaki, A., AbdEl Moniem, N. Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC. EKB Journal Management System, 2018; 39(1): 208-217. doi: 10.21608/ejhm.2018.16964

Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC

The Egyptian Journal of Hospital Medicine
Article 7, Volume 39, Issue 1, April 2018, Pages 208-217    PDF (1.1 M)
Document Type: Original Article
DOI: 10.21608/ejhm.2018.16964
Authors
MohamedA. EzzelArab1; MohammadA. Hassanein2; Mohamed Hassany2; SalahEldeenM. Ahmad2; AminM. AbdElBaki2; NashwaA. AbdEl Moniem3
1Internal Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt
2Tropical Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt
3Clinical Pathology Department -National Hepatology And Tropical Medicine Research
Abstract
Background:Hepatocellularcarcinoma(HCC)isthefifthmostcommonmalignancyinthe world.InEgypt,HCCwasreportedtoaccountforabout4.7%ofchronicliverdisease(CLD) patients.Squamouscellcarcinomaantigen(SCCA)hasbeenreportedtobestronglyexpressed inHCCtissuehamperingitsextensiveuseinclinicalpractice.
Aim:Studythevalueofserumsquamouscellcarcinomaantigen(SCCA)forscreeningof HCC.
Materials&Method:Thestudycomprisedoftwogroups.GroupAincluded60patientswith HCCdiagnosticallyconfirmedbyspiralCT,elevatedalfa-fetoprotein(AFP),and/orliverbiopsy .GroupBCLDpatientsdiagnosedonclinical,laboratory,andultrasonographicalinvestigations; groupBsuclassifiedintothreecategoriesaccordingtoCHILD-PUGHscoreincluded30 patients,matchedforsexandage.Allgroupsweresubjectedtothoroughhistorytaking,full clinicalexamination,andlaboratoryinvestigationsincludingliverfunctions,viralmarkers,and AFPandSCCAestimationusingELISAtechnique.
Results:ThisstudyrevealedahighlysignificantdifferencebetweenpatientswithHCCand CLDregardingserumSCCAlevelsbeinghigheringroupA(10.35±20.677)thangroup B(1.64±2.462)(p=0.02).SCCAlevelwaselevatedinpatientswithHCCwithnormalAFPlevels representingitsusefulroleinearlydetectionandfollow-upofpatientstreatedforHCC.The cut-offvaluewasestablishedat2ng/mlwithsensitivityof80%andspecificityof70%).
Conclusion:SCCAcouldrepresentausefultoolasamarkerfordetectionofHCC.

Keywords
Hepatocellularcarcinoma; squamouscellcarcinomaantigen; tumormarkers
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