Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC | ||
The Egyptian Journal of Hospital Medicine | ||
Article 7, Volume 39, Issue 1, April 2018, Pages 208-217 PDF (1.1 M) | ||
Document Type: Original Article | ||
DOI: 10.21608/ejhm.2018.16964 | ||
Authors | ||
MohamedA. EzzelArab1; MohammadA. Hassanein2; Mohamed Hassany2; SalahEldeenM. Ahmad2; AminM. AbdElBaki2; NashwaA. AbdEl Moniem3 | ||
1Internal Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt | ||
2Tropical Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt | ||
3Clinical Pathology Department -National Hepatology And Tropical Medicine Research | ||
Abstract | ||
Background:Hepatocellularcarcinoma(HCC)isthefifthmostcommonmalignancyinthe world.InEgypt,HCCwasreportedtoaccountforabout4.7%ofchronicliverdisease(CLD) patients.Squamouscellcarcinomaantigen(SCCA)hasbeenreportedtobestronglyexpressed inHCCtissuehamperingitsextensiveuseinclinicalpractice. Aim:Studythevalueofserumsquamouscellcarcinomaantigen(SCCA)forscreeningof HCC. Materials&Method:Thestudycomprisedoftwogroups.GroupAincluded60patientswith HCCdiagnosticallyconfirmedbyspiralCT,elevatedalfa-fetoprotein(AFP),and/orliverbiopsy .GroupBCLDpatientsdiagnosedonclinical,laboratory,andultrasonographicalinvestigations; groupBsuclassifiedintothreecategoriesaccordingtoCHILD-PUGHscoreincluded30 patients,matchedforsexandage.Allgroupsweresubjectedtothoroughhistorytaking,full clinicalexamination,andlaboratoryinvestigationsincludingliverfunctions,viralmarkers,and AFPandSCCAestimationusingELISAtechnique. Results:ThisstudyrevealedahighlysignificantdifferencebetweenpatientswithHCCand CLDregardingserumSCCAlevelsbeinghigheringroupA(10.35±20.677)thangroup B(1.64±2.462)(p=0.02).SCCAlevelwaselevatedinpatientswithHCCwithnormalAFPlevels representingitsusefulroleinearlydetectionandfollow-upofpatientstreatedforHCC.The cut-offvaluewasestablishedat2ng/mlwithsensitivityof80%andspecificityof70%). Conclusion:SCCAcouldrepresentausefultoolasamarkerfordetectionofHCC. | ||
Keywords | ||
Hepatocellularcarcinoma; squamouscellcarcinomaantigen; tumormarkers | ||
Statistics Article View: 248 PDF Download: 456 |