CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF VERBENA SUPINA L ; GROWING IN EGYPT | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 1, Volume 12, Issue 1, June 2003, Page 1-8 PDF (3.84 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.2003.169695 | ||||
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| Authors | ||||
Mahmoud Abdel-Aal  1; Salah Ghareib2
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| 1Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University,Zagazig, Egypt | ||||
| 2Department of Pharmacology, Faculty of Pharmacy, Zagazig University,Zagazig, Egypt | ||||
| Abstract | ||||
| Phytochemical investigation of the chloroform extract of Verbena supina L. afforded ursolic acid, oleanolic acid, 3β, 24-dihydroxy-urs-12-en-28-oic acid and 3 β,24-dihydroxy-olean-12-en-28-oicacid.The ethyl acetate extract yielded the pheny1propanoid acteoside. The isolated materials were identified on the bases of chromatographic spectroscopic (UV, JR, 1H and 13C-NMR and MS) evidences. Chloroform extract, ursolic acid and 3β,24-dihydroxy-urs-12-en-28-oic acid exhibited potent anti-inflammatory activities in comparison with hydrocortisone using carrageenan- induced hind paw edema model. | ||||
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