Luteal phase Vitamin C supplementation on the outcome of in-vitro fertilization | ||||
| The Egyptian Journal of Fertility and Sterility | ||||
| Article 4, Volume 25, Issue 2 - Serial Number 11106352, May 2021, Page 28-35 PDF (1.74 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2021.170463 | ||||
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| Author | ||||
| Mostafa Abdulla Elsayed Mahmoud | ||||
| Assistant professor of obstetrics and gynecology Benha University | ||||
| Abstract | ||||
| Background: In-vitro fertilization is successful Assisted Reproductive Technology for infertility became one of the best modalities for achieving the dream of having children in face of many obstacles in fertility, many works have been done to enhance the outcome of IVF especially the live birth rate and all methods tried to support the luteal phase with many medications. Objective: To evaluate the effect vitamin C supplementation at dose of 1000mg per day on the day of oocyte retrieval on the outcome of the In-vitro fertilization. Methodology: A randomized open-label study was carried out on 200 women undergoing In-vitro fertilization for infertility treatment conducted at AlShorouk IVF clinic Benha city egypt. They were randomly divided in two groups; one group received 1000 mg/day oral Vitamin C supplementation 1000mg divided into two capsules by day and night on the day of oocyte retrieval along with the standard treatment protocol of In-vitro fertilization and other group received standard treatment long protocol for the In-vitro fertilization only. Pregnancy test done after 14 days and pregnant patient followed by regular visits till reaching term and any morbidity recorded. Results: Significant outcome regarding reaching full term pregnancy occurred in the vitamin c group with number of full term pregnancies 65 out of 100 (65%) compared to only 45 out of 100 in the control group (45%) with p value 0.004 also the rate of early miscarriage is higher in the control group 20% and only 8% in the vitamin c study group with p value 0.01. Conclusion: Vitamin C supplementation has significantly improved the outcome of In-vitro fertilization techniques with reduced incidence of spotting and miscarriages along with improved term pregnancy. However a multimodal approach of analgesia/anaesthesia for TUGOR is recommended to further improve on clients’ satisfaction and acceptance. | ||||
| Keywords | ||||
| Keywords: In-vitro fertilization; Vitamin C; Infertility; full term pregnancy | ||||
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