Synthesis of New 5-Aryl Tetrazoline from N-Aceto Hydrazide Cyclic Imides and Study of Biological Activity | ||
| Egyptian Journal of Chemistry | ||
| Article 25, Volume 64, Issue 10, October 2021, Pages 5647-5653 PDF (731.18 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.70531.3554 | ||
| Authors | ||
| Akram Al-Haidari* ; Entesar AL-Tamimi | ||
| Department of chemistry, College of Sciences, Baghdad University, Baghdad, Iraq. | ||
| Abstract | ||
| The research resulted in the production of new tetrazoline derivatives. Firstly; the reaction of N-acetyl chloro cyclic imides with hydrazine hydrate to give compounds (1,2). Then, compounds (1,2) were reacted with different aromatic aldehydes to give Schiff bases (3-10). The compounds of N-( 2-chloro acetyl) cyclic imides were reacted with sodium azide to give N-(azido acetyl) cyclic imides (11,12). Finally, the reaction of the prepared Schiff bases compounds with azide compounds and cyclization to gave 5-aryl tetrazoline on cyclic imides (13-20). The prepared compounds were characterized by Fourier transform infrared spectroscopy (FT-IR) and some of them byProton nuclear magnetic resonance (1H-NMR), melting point, and were studied the effects of the preparing compounds on some strains of bacteria and fungi. | ||
| Keywords | ||
| cyclic imides; Schiff bases; sodium azide; tetrazoline; antibacterial | ||
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