Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity
Ali, I., Said, M., AlWazn, W. (2021). Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity. EKB Journal Management System, 64(10), 5703-5712. doi: 10.21608/ejchem.2021.72890.3614
Ibtisam Ali; Mohammed Hamid Said; Wafaa AlWazn. "Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity". EKB Journal Management System, 64, 10, 2021, 5703-5712. doi: 10.21608/ejchem.2021.72890.3614
Ali, I., Said, M., AlWazn, W. (2021). 'Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity', EKB Journal Management System, 64(10), pp. 5703-5712. doi: 10.21608/ejchem.2021.72890.3614
Ali, I., Said, M., AlWazn, W. Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity. EKB Journal Management System, 2021; 64(10): 5703-5712. doi: 10.21608/ejchem.2021.72890.3614

Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity

Egyptian Journal of Chemistry
Article 30, Volume 64, Issue 10, October 2021, Page 5703-5712  XML PDF (1.1 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.72890.3614
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Authors
Ibtisam Ali email 1; Mohammed Hamid Said2; Wafaa AlWazn3
1Department of Chemistry, College of Science, Kerbala University
2Department of Chemistry, College of Science for women, University of Babylon, Iraq
3The Department of Biology, College of Science, Kerbala University, Iraq
Abstract
The reaction of 6-amino pencillanic acid with Schiff base “(Z)-3-((3-hydroxybenzylidene) amino) phenol)” has formed a novel Azo–azomethine ligand (HL) “(7-((Z)-(2-hydroxy-4-((Z)-((3-hydroxyphenyl) imino) methyl) phenyl) diazenyl)-3, 3- dimethyl-6-oxo-2-thiabicyclo [3.2.0] heptane-4-carboxylic acid”. The ligand (HL) is characterized by 1H-NMR, 13 C-NMR, Mass Spectrometry, CHNs, Uv-Visible, and FT-IR. This new Ligand (HL) is used to prepare numerous complexes using transition metal ions Fe (II) Cu (II), and Ni (II). These complexes’ properties are studied using different techniques such as Mass Spectroscopy, Atomic Absorption, FT-IR, UV-Visible, Magnetic Moment, and Molars Conductivity. All these techniques indicate 1:2 (M: L) stoichiometry’s synthesized complexes. Azo-azomethine ligand (HL) acts as a tridentate ligand to form the octahedral shape complexes with sp3d2, d2sp3 Hybridization. These new ligands and complexes are studied for their biological activity. The results show that the minimum inhibition concentration (MIC) of the prepared compounds has inhibition activity against Staphylococcus aureus bacteria and obviously affects the ability of pathogenic bacteria (S. aureus) to attain virulence factors such as Biofilm and hemolysin toxin
Keywords
β-Lactam; Schiff base; 6-Amino penicillanic; Antibacterial activity
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