Studies on the effect of antioxidant Selenium-ACE after treatment with Praziquantel and Mirazid in Schistosoma mansoni infected mice
Emam, M., Abd El-Rahman, M., Gamil, I., Muselhy, M. (2009). Studies on the effect of antioxidant Selenium-ACE after treatment with Praziquantel and Mirazid in Schistosoma mansoni infected mice. EKB Journal Management System, 37(1), 709-725. doi: 10.21608/ejhm.2009.17482
Muhammad Hamdy Emam; Mona Abd El-Rahman; Irene Sameh Gamil; Marwa Ahmed Muselhy. "Studies on the effect of antioxidant Selenium-ACE after treatment with Praziquantel and Mirazid in Schistosoma mansoni infected mice". EKB Journal Management System, 37, 1, 2009, 709-725. doi: 10.21608/ejhm.2009.17482
Emam, M., Abd El-Rahman, M., Gamil, I., Muselhy, M. (2009). 'Studies on the effect of antioxidant Selenium-ACE after treatment with Praziquantel and Mirazid in Schistosoma mansoni infected mice', EKB Journal Management System, 37(1), pp. 709-725. doi: 10.21608/ejhm.2009.17482
Emam, M., Abd El-Rahman, M., Gamil, I., Muselhy, M. Studies on the effect of antioxidant Selenium-ACE after treatment with Praziquantel and Mirazid in Schistosoma mansoni infected mice. EKB Journal Management System, 2009; 37(1): 709-725. doi: 10.21608/ejhm.2009.17482

Studies on the effect of antioxidant Selenium-ACE after treatment with Praziquantel and Mirazid in Schistosoma mansoni infected mice

The Egyptian Journal of Hospital Medicine
Article 9, Volume 37, Issue 1, October 2009, Pages 709-725    PDF (668.37 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2009.17482
Authors
Muhammad Hamdy Emam1; Mona Abd El-Rahman2; Irene Sameh Gamil2; Marwa Ahmed Muselhy2
1Parasitology Department, Faculty of Medicine, Al-Azhar University
2Zoology Department, Faculty of Science, Helwan University
Abstract
Background: This study deals with the evaluation of parasitological, histopathological and biochemical effect of Praziquantel (PZQ) and Mirazid (MZ) with or without Selenium-ACE (Se-ACE) on male albino mice infected with S.mansoni and trying to evaluate the antioxidant effect of Se-ACE and its role in reducing the severity of the infection.
Results: The obtained results indicated that treatment with PZQ produced more reduction in worm burden and ova count/gm liver than MZ compared to the infected control group. PZQ showed the highest reduction in liver granuloma number and diameter when compared to MZ group while both drugs showed a significant effect in restoration of the liver transaminases and protein fractions towards their normal levels indicating the safety of both drugs as anti S. mansoni chemotherapeutics, Se-ACE showed a high efficacy as a co-treatment, potentiating the effect of PZQ and MZ in reducing the worm burden, ova count/gm liver, number and diameter of liver granuloma and restoration of liver transaminases and protein fractions to their normal levels during treatment of S. mansoni infection.
Conclusion: the rank order of potency in protection against liver cell damage was PZQ 500 mg/kg > MZ 600 mg/kg where Se-ACE showed a couraging criterion as a co- treatment potentiating the effect of the antischistosomal medications through its anti- oxidant activity.
 
Keywords
praziquantel; Mirazid; Selenium –ACE; S. mansoni and co-treatment
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