Neuromodulatory Influences of vitamin C on D-galactose Induced Neuronal Metabolic Dysfunction Model | ||
| Benha Veterinary Medical Journal | ||
| Article 16, Volume 40, Issue 1, March 2021, Pages 80-83 PDF (902.25 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bvmj.2021.67215.1360 | ||
| Authors | ||
| Mohammed Mohammed* 1; Fatma Moawed2; omayma Abo zaid1; Omama Elshewyi2 | ||
| 1Biochemistry Department Faculty of Veterinary Medicine , Banha University | ||
| 2Health radiation research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt | ||
| Abstract | ||
| Aging is a physiological, non-pathological process that occurs mainly as a slow, gradual, and passive procedure influenced by interplay of numerous genetic and environmental influences. Different ways have been tried to postponement aging and extent life span in animals, dietary anti-oxidants are one of them. Depending on the metabolic and free radical theories of aging, this work was carried out to evaluate the use of vitamin C in delaying the aging promoter. D galactose shedding the light on aging mechanisms underlying the anti-aging variations on both the molecular and the physiological level. Aging was enhanced by injecting rats subcutaneously with D galactose in a dose of 100 mg for 8 weeks brain tissues were subjected to analysis determining the level of serotonin, dopamine and nor epinephrine. D galactose caused down regulation of both serotonin and dopamine while nor epinephrine went up, such alteration has been resisted in rats administrated vitamin C. Thus we can conclude that anti-oxidants could prevent the age related brain deterioration. | ||
| Keywords | ||
| aging; anti-oxidants; vitamin C; D-galactose | ||
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