SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 2, Volume 13, Issue 2, December 2004, Pages 6-15 PDF (3.75 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.2004.177894 | ||
| Authors | ||
| Zakaria Abd El-Samii* 1; Said El-Feky1; Hanan Abedel-Fattah2; Mahmoud Soliman2 | ||
| 1Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||
| 2Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||
| Abstract | ||
| 4-Chloro-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (3) was reacted with 4-aminoacetophenone in ethanol to give 4(4- acetylanilino)5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (4). Compound 4 was used as a key intermediate for the synthesis of several pyrazoles 6-8, pyridones 13, 14, thiazoles 15, 17 and thiazolidinones 18, 19. On the other hand, compound 3 was fused with ethyl 2-amino-4,5,6,7-tetrahydrobenzofbthiophene-3-carboxylate and anthranilic acid to give compound 9 and 10 respectively. Compound 14b showed the same antiinflammatory activity as that of the reference drug dichlofenac sodium. | ||
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