Inflammatory Markers in Pre-eclampsia | ||||
| Egyptian Journal of Chemistry | ||||
| Article 40, Volume 64, Issue 11, November 2021, Page 6523-6527 PDF (303.27 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.79199.3887 | ||||
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| Authors | ||||
Sura Khairialdeen Mohialdeen   1; Sahar B. Aziz2
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| 1University of Mosul, Mosul, Iraq | ||||
| 2University of Mosul/ College of Medicine/ Department of Biochemistry, Mosul, Iraq. | ||||
| Abstract | ||||
| Pre-eclampsia, a hypertensive disorder that affects some pregnants, is considered as a major cause of maternal and fetal death. Inflammation and oxidative stress may contribute to the pathophysiology of pre-eclampsia.The aim of this study is to evaluate the values of oxidative stress parameters and inflammatory markers in blood of normal and pre-eclamptic pregnants. In 25 pre-eclamptic and 25 normotensive pregnant women we determined serum levels of malondialdehyde, peroxynitrite, C-reactive protein, and tumor necrotizing factor alpha. Urinary protein was tested to determine proteinuria. The results show that in pre-eclampsia group; serum malondialdehyde, peroxynitrate, C-reactive protein, and tumour necrotizing factors alpha levels were significantly higher than in normotensive group. Serums malondialdehyde showed significant positive correlation with C-reactive protein (P=0.013) and tumour necrotizing factors alpha (P=0.000). In conclusion; The inflammatory markers (C-reactive protein and tumour necrotizing factors alpha) and oxidative stress markers (malondialdehyde and peroxynitrate) are all increased in pre-eclampsia. This data suggest the possibility of inflammation and oxidative stress in pre-eclampsia. | ||||
| Keywords | ||||
| pre-eclampsia; oxidative stress markers; malondialdehyde; inflammatory markers; tumour necrotizing factors alpha | ||||
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