Evaluation of the Effect of Low Level Laser Therapy and Synovial Fluid-Mesenchymal Stem Cells in Cases of Temporomandibular Joint Disorders | ||
| Egyptian Journal of Oral and Maxillofacial Surgery | ||
| Article 4, Volume 11, Issue 3, July 2020, Pages 103-110 PDF (340.16 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/omx.2021.51515.1101 | ||
| Author | ||
| Mosaad Khalifah* | ||
| Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kafrelsheikh University, Kafrelsheikh, Egypt | ||
| Abstract | ||
| Purpose: Temporomandibular joint disorders (TMD) might be the main cause of the non-dental orofacial pain. Various treatment modalities were introduced to treat that condition. Low level laser therapy (LLLT) had an anti-inflammatory and analgesic effect by enhancing the circulation and the cellular respiration. Synovial fluid-mesenchymal stem cells (SF-MSCs) had a regenerative and immunoregulatory effect. Both methods were applied as a treatment for the condition; but with no comparative studies in the literature. So, the current study aimed at evaluating their therapeutic effects. Material and methods: A total of 27 patients with TMD in 40 TMJs were randomly divided into two equal groups. In group I, LLLT was applied at four successive weeks. For group II, SF-MSCs were isolated, proliferated and pooled at Passage 4 to be injected into the joint space at four successive weeks. Results: SF-MSCs therapy was superior to the LLLT with regards to the enhancement of the maximum mouth opening and the reduction of the inflammatory cytokines IL-1β and TNFα. With regards to interleukin-6, there was no statistically significant difference. However, for pain reduction, LLLT was better than SF-MSCs; but not after the third week. Conclusion: Both treatment methods are accepted modalities; but SF-MSCs were more superior and had more sustained results. | ||
| Keywords | ||
| Cytokines; Low level laser therapy; Regeneration; Synovial fluid-mesenchymal stem cells; Temporomandibular joint disorders | ||
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