Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 4, Volume 12, Issue 1, June 2003, Page 24-28 PDF (2.07 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.2003.178067 | ||||
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Author | ||||
Samy Sakr ![]() | ||||
Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. | ||||
Abstract | ||||
A new series of 2,3-dihydro-4(1H)-quinazolinones was synthesized by condensation of 2-methylamino-N-substituted benzamides (III) with either formaldehyde or aromatic aldehydes to produce 2,3-dihydro-1-methyl-3-(substituted phenyl)-4(1H) -quinazolinones (V) and 2,3-dihydro-2,3-di(substituted phenyl)-1-methyl-4(1H)-quinazolinones (VI) respectively. The anti-inflammatory study of some of the prepared compounds revealed that compound (Vla) showed significant activity in comparison with flufenamic acid. | ||||
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