Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives
Sakr, S. (2003). Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives. EKB Journal Management System, 12(1), 24-28. doi: 10.21608/zjps.2003.178067
Samy Sakr. "Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives". EKB Journal Management System, 12, 1, 2003, 24-28. doi: 10.21608/zjps.2003.178067
Sakr, S. (2003). 'Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives', EKB Journal Management System, 12(1), pp. 24-28. doi: 10.21608/zjps.2003.178067
Sakr, S. Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives. EKB Journal Management System, 2003; 12(1): 24-28. doi: 10.21608/zjps.2003.178067

Synthesis and Anti-inflammatory Activity of New 2,3-Dihydro-4(1H)-quinazolinone Derivatives

Zagazig Journal of Pharmaceutical Sciences
Article 4, Volume 12, Issue 1, June 2003, Pages 24-28    PDF (2.07 M)
Document Type: Original Article
DOI: 10.21608/zjps.2003.178067
Author
Samy Sakr*
Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Abstract
A new series of 2,3-dihydro-4(1H)-quinazolinones was synthesized by condensation of 2-methylamino-N-substituted benzamides (III) with either formaldehyde or aromatic aldehydes to produce 2,3-dihydro-1-methyl-3-(substituted phenyl)-4(1H) -quinazolinones (V) and 2,3-dihydro-2,3-di(substituted phenyl)-1-methyl-4(1H)-quinazolinones (VI) respectively.
The anti-inflammatory study of some of the prepared compounds revealed that compound (Vla) showed significant activity in comparison with flufenamic acid.
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