Diagnostic Value of Serum Angiopoietin-2 in Patients with Hepatocellular Carcinoma | ||
| Afro-Egyptian Journal of Infectious and Endemic Diseases | ||
| Article 10, Volume 5, Issue 4, December 2015, Pages 288-296 PDF (323.97 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aeji.2015.17850 | ||
| Authors | ||
| Mohamed Alaa El Din Nouh1; Sawsan El-Sayed Anees1; Ayman El-Lehleh1; Wafaa Mahmoud Radwan2; Moamena Said El-Hamoly* 1 | ||
| 1Tropical Medicine Department, Faculty of Medicine, Menoufiya University ,Egypt | ||
| 2Clinical Pathology Department, Faculty of Medicine, Menoufiya University,Egypt. | ||
| Abstract | ||
| Background and study aim: Hepato-cellular carcinoma (HCC) is a hypervascular tumor and its progression is known to be closely related to angiogenesis. Angio-poietin-2 (Ang-2) is one of the angiogenic factors that may have a diagnostic value in HCC. Alpha-fetoprotein (AFP) serum levels are used for screening for HCC with limited success. This study aimed to evaluate diagnostic value in using angio-poietin-2 as a serum marker in HCC patients. Patients and Methods: 50 patients with HCC (G1), 20 patients with liver cirrhosis (G2), and 20 healthy control persons (G3) were included in this study. Serum AFP and Ang-2 levels were measured by enzyme-linked immunosorbent assay. Results: Serum Ang-2 levels in the HCC group (1523.54±886.46 pg/ml) was highly significantly elevated as compared to those with cirrhotic liver (222.55±153.60 pg/ml) and controls (138.35±54.09 pg/ml). The Ang-2 levels were significantly different between patients with liver cirrhosis and controls. In HCC patients, the serum Ang-2 levels in patients with portal vein (PV) thrombosis (n=7, 2164.0±960.85 pg/ml) and with large HCC (>5cm in diameter) (n=17, 2017.70±903.06 pg/ml) were significantly higher than those without PV thrombosis (n=43, 1274.47±727.56 pg/ml) and with small HCC (≤5cm in diameter) (n=33, 1268.97±773.93 pg/ml), while the serum AFP levels in patients with portal vein (PV) thrombosis (961.05±1007.70 ng/ml) and with large HCC (>5cm in diameter) (1000.81±1079.57 ng/ml) were not significantly higher than those without PV thrombosis (500.24±733.07 ng/ml) and with small HCC (437.87±611.02 ng/ml). Conclusion: Combined measurement of serum AFP and Ang-2 significantly increases the sensitivity and specificity of HCC detection rather than using of AFP or Ang-2 separately. | ||
| Keywords | ||
| Alpha-fetoprotein (AFP); Angiopoietin-2 (Ang-2); Hepatocellular carcinoma (HCC) | ||
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