Using Microwave and ultrasound to prepare of substituted Bis-acyl hydrazone Derivatives | ||
| Egyptian Journal of Chemistry | ||
| Article 27, Volume 64, Issue 11, November 2021, Pages 6423-6427 PDF (454.8 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.78532.3842 | ||
| Authors | ||
| Salim J. Mohammed1; Attallah M. Sheat1; Salih A. Abood1; Omar M. Yahya2 | ||
| 1Department of Chemistry, College of Science, Mosul University, Mosul, Iraq | ||
| 2Department of Biochemistry, College of Medicine, Mosul University, Mosul-Iraq | ||
| Abstract | ||
| Abstract In this paper, some new bis-aryl hydrazone derivatives (4a-f) were prepared through the reaction of carboxylic acid hydrazides with 1,4-diacetylbenzene using classical methods, microwave and ultrasound irradiation methods. These compounds are obtained through a series of reactions where some carboxylic acids react with ethanol first in the presence of concentrated sulfuric acid to give the corresponding esters (2a-f), which when treatment with aqueous hydrazine give carboxylic acid hydrazides (3a-f).thus, The results proved that the use of microwave and ultrasound techniques is much better than the classical methods, as it gave a higher yield, shorter reaction time, and the absence of the use of solvents. All newly synthesized compounds were confirmed by IR, (1H & 13C) NMR spectral analysis and the corresponding reactions were monitored by TLC using the reported eluent | ||
| Keywords | ||
| Keywoords: bis-acyl hydrazone; acid hydrazide; 1; 4-diacetylbenzene; Microwave; ultrasound technique | ||
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