Synthesis and Reactions of Some Thiazole Derivatives | ||
| Catrina: The International Journal of Environmental Sciences | ||
| Article 1, Volume 8, Issue 1, 2013, Pages 1-4 PDF (54.5 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0010669 | ||
| Authors | ||
| Sahar El-Sakka* ; Mohamed Soliman; Rokaia Abdullah | ||
| Chemistry Department, Faculty of Science, Suez University, Suez, Egypt | ||
| Abstract | ||
| A series of novel 2-aminothiazole derivatives (3a-e) has been synthesized by the reaction of 4-[4- methoxy-3-methylphenyl]-4-oxobutenoic acid (1) with thiourea derivatives (2a-e). The thiazolopyridazine derivatives (4a-c) and (5) were obtained from the reaction of 4-hydroxy-1,3-thiazole (3a-e) with hydrazine and phenylhydrazine, respectively. The behavior of the 4-hydroxy-1,3-thiazole (3a-e) toward acetic anhydride and bromine was also studied. The proposed structures of the products were based on microanalytical and spectroscopic data. | ||
| Keywords | ||
| β-Aroylacrylic Acid; thiazole; Thiazolopyridazine; thiourea | ||
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