Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 6, Volume 24, Issue 1, July 2006, Pages 477-483 PDF (683.26 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2006.17910 | ||
| Authors | ||
| Hanan M.A. Darwish; Nahla M. Abd EL-Aziz* ; Fatma M. EL-Marzouky | ||
| Departments of Dermatology and Venereology & Clinical pathology Faculty of Medicine for Girls AL-AZhar University | ||
| Abstract | ||
| Background : Psoriasis is a common inflammatory skin disorder, has received attention as a target for new pathogenesis and oriented therapies . Autoimmunity and T lymphocyte subsets are suggested to be involved in the development of psoriasis. The aim of this work is to asses the role of T lymphocyte subsets in the pathogenesis of psoriasis . Material And Methods :We investigated the peripheral blood lymphocyte subpopulations obtained from psoriatic patient before and after treatment and from healthy controls, using two colour flow cytometry. Results :We found highly significant suppression of total CD3+ T Cells and CD3+ CD56+ NKT lymphocytes in psoriatic patient as compared to control. Also, we observed significant reduction of T helper cells in patients as compared to control. Conclusion : The highly significant reduction of CD3+ T cell and CD3+ CD56+ NKT lymphocytes proved their actively involvement in the development of psoriasis. | ||
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