The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)
Waer, H., Edress, S. (2006). The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies). EKB Journal Management System, 24(1), 524-538. doi: 10.21608/ejhm.2006.17916
Hanaa F. Waer; Saleh Edress. "The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)". EKB Journal Management System, 24, 1, 2006, 524-538. doi: 10.21608/ejhm.2006.17916
Waer, H., Edress, S. (2006). 'The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)', EKB Journal Management System, 24(1), pp. 524-538. doi: 10.21608/ejhm.2006.17916
Waer, H., Edress, S. The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies). EKB Journal Management System, 2006; 24(1): 524-538. doi: 10.21608/ejhm.2006.17916

The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)

The Egyptian Journal of Hospital Medicine
Article 10, Volume 24, Issue 1, July 2006, Pages 524-538    PDF (2.15 M)
Document Type: Original Article
DOI: 10.21608/ejhm.2006.17916
Authors
Hanaa F. Waer; Saleh Edress
National Center for Radiation Research and Technology, Atomic Energy Authority Faculty of Medicine,Banha University
Abstract
Foodadditivesarechemicalsubstancesaddedintentionallytofoodstuffstopreserve, color,sweetenandflavorfood.Monosodiumglutamate(MSG)isusedasaflavorenhancerand foundinmostsoups,saladdressingandprocessedmeat.TheuseofMSGinfoodisgrowing. Irrationalfearhadincreasedinthelastfewyearsduetotheadversereactionsandtoxicityof MSG.
ThepresentstudywasdesignedtoinvestigatetheeffectofMSGontheratliverandthe amelioratingeffectoftaurineanalog“Guanidinoethanesulfonicacid(GES)”.Sixtyalbinorats (2-3monthsold)wereusedinthepresentstudy.MSGwasgivenorallyatadailydoseof60 mg/1000gforonemonth,twomonthsandwasgivenatadailydoseof100mg/1000gmforone month.TheresultsrevealedthatthedeleteriouseffectsofMSGweredoserelatedand cumulative.InMSGtreatedrats,theexaminedsectionsshowedremarkablealterationsvaried considerablyfrommoderatestructuralchangestocytoplasmiclysisandsignsofdegenerationof cellularorganelles.Thehistologicalchangesshoweddisturbedliverarchitecture,hemorrhagein thecentralveins,areasofnecrosis,vacuolationandincreasedinflammatorycellsinfiltration. Theglycogengranulesincreasedaswellasthecollagenfibersinthelivercells.Ultrastructural changesshowedlossofcytoplasmicdifferentiation,vacuolation,pyknoticnucleiwithirregular nuclearmembranesandelongatedelectrondensemitochondria.Conversely,treatmentofrats withtaurineanalog(GES)significantlyattenuatedthecellulartoxicityofMSG.
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