A Histological Study on the Possible Adverse Effect of Sofosbuvir on Lungs of Adult Male Albino Rats | ||
| Journal of Medical Histology | ||
| Article 9, Volume 4, Issue 1, June 2020, Pages 119-125 PDF (1.62 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmh.2020.33529.1077 | ||
| Authors | ||
| Sara Hosny* ; Manal Abdel Mohsen; Marwa Mohamed Sabry Sabry | ||
| Departments of of Histology, Faculty of Medicine, Cairo university, Egypt. | ||
| Abstract | ||
| Background: In 2011, three new direct-acting antivirals (DAAs) for HCV including sofosbuvir were accredited for HCV management. Aim: To evaluate the impact of Sofosbuvir treatment on the histological structure of the lungs of adult male albino rat. Materials and Methods: 15 male rats were classified into: control group of 5 rats and sofosbuvir treated group of 10 rats that received sofosbuvir orally in a dose of 4 mg/kg per day for 5 weeks. Blood samples were drawn to assess serum Transforming growth factor- β (TGF-β). Lung specimens were obtained for evaluation by light microscope. Alpha smooth Muscle Actin (α-SMA), E-cadherin immunohistochemistry, and statistical analysis were applied. Results: Marked increase in the mean value of serum TGF-β in Sofosbuvir treated group when compared to control group. Sofosbuvir resulted in histological and immunohistochemical changes in the lungs of sofosbuvir treated rats. Conclusion: Severe lung injury was detected after treatment with sofosbuvir. However further studies should be done to determine the exact mechanism and more caution should be taken during administration of sofosbuvir. | ||
| Keywords | ||
| Alpha smooth muscle actin; E-cadherin; Lung; sofosbuvir; TGF-β | ||
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