MOLLUSCICIDAL STEROIDAL SAPONINS FROM YUCCA ELEPHANTIPES | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 8, Volume 10, Issue 1, June 2001, Pages 41-48 PDF (3.68 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.2001.181595 | ||
| Authors | ||
| Mortada El-Sayed* 1; Hanan El-Nahas2 | ||
| 1Laboratory of Medicinal Chemistry, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt. | ||
| 2Department of Medicinal Chemistry Theodor Bilharz Research Institute Warrak El-Hadar, Giza, Egypt. | ||
| Abstract | ||
| Three spirostanol and two furostanol saponins have been isolated from the methanol extract of the leaves of Yucca elephantipes .The structures of these saponins were established as 3-O-β -D-xylopyranosyl-(1→2)- B-D- glucopyranosyl-(1→3)- β-D-glucopyranoside D- galactopyranoside yamogenin (I),3-O-β-D-xylopyranosyl-(1-→2)[ -β-D- glucopyranosyl-( 1-3 )] , 26-B-D- glucopyranoside (25 S) -furost- 5-ene-3,22,26 -triol (II), 3- O- α -L -rhamnopyranosyl- ( 1→2 )-[ β- D-xylopyranosyl- (1-→3) -β-D-glucopyranosyl-(1–>4)- β-D-galactopyranoside gitogenin (III), 3-O-β-D-xylopyranosyl- ( 1→ 3)- [β-D-glucopyranosyl -(1→2) - ß-D-glucopyranosyl-(1→4)- β- D-galactopyranoside gitogenin (IV),and 26-0-β-D-glucopyranosyl-22-0-methyl (25R)-5-furostan -2,3,26-tetrol-3-O-[α-L-rhamnopyranosyl -(1->3)]- ß -D-glucopyranosyl -(1->2)- β-D-glucopyranosyl-(1-4)- β-D- galactopyranoside (V). Saponins I, III and IV showed high molluscicidal activities against Biomphalaria alexandrina snails after 24 hours exposure (LC90 = 4,9 and 7 ppm ) whereas saponins II and V were inactive up to 50 ppm | ||
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