SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 2, Volume 9, Issue 1, June 2000, Pages 9-16 PDF (3.25 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.2000.181618 | ||
| Authors | ||
| Osama El-Sabbagh* 1; Abd-El Alim Abd-El Alim2 | ||
| 1Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||
| 2Depart. of Pharmacology, Faculty of Vet. Medicine , Zagazig University, Zagazig, Egypt. | ||
| Abstract | ||
| Two series of 8-chloro-2, 3, 4, 5,10,11-hexahydro-11-substituted-1H-dibenzob,e 1,4 diazepine-1-ones and their3,3- dimethyl analogs were prepared via internal Mannich reaction of 3-[(2- amino-4- chlorophenyl) amino] -2-cyclohexen-1-one and its 5,5-dimethyl analog, respectively, with different aldehydes at room temperature. The synthesized compounds were evaluated for their clozapine-like properties. The structures of the novel compounds were confirmed using elemental analyses and different spectroscopic methods. Pharmacological evaluation of some of the synthesized dibenzodiazepine derivatives revealed that compounds 4 and 17 (having 4-bromophenyl moiety) exhibited a high antipsychotic and sedative properties. | ||
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