Synthesis, Characterization of Some Copper (II) Complexes with Ampicillin Derivatives and Study their Biological Activity | ||
| Egyptian Journal of Chemistry | ||
| Article 39, Volume 64, Issue 12, December 2021, Pages 7235-7240 PDF (517.81 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.77649.3789 | ||
| Authors | ||
| Nahed H. Al-Haidery1; Naeem Failli2; Hanan Al-Hazam3 | ||
| 1Chemistry, science faculty, university of Basrah, Iraq | ||
| 2Chemistry, Science faculty, university of Basrah, Iraq | ||
| 3Chemistry, Science faculty, University of Basrah, Iraq | ||
| Abstract | ||
| New metal ion complexes of ampicillin were synthesis by two steps, first by N-acylation with benzoyl chloride and sebacoyl chloride, In the second step, the prepared compounds were reacted with cupric ion to form Cu- complexes. FT-IR, 1H NMR, 13C NMR, UV- visible, Elemental analysis, and, a theoretical study was used to distinguish the prepared complexes. The biological efficacy of synthesis compound was found more active against the bacteria. | ||
| Keywords | ||
| Ampicillin; Copper (II) complexes; antibacterial activity; AM1 semi-empirical | ||
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