SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW ARYLSULPHONYLUREA AND THIOUREA DERIVATIVES
Abou-Kull, M., Amer, M. (1999). SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW ARYLSULPHONYLUREA AND THIOUREA DERIVATIVES. EKB Journal Management System, 8(2), 40-45. doi: 10.21608/zjps.1999.184156
Mansour Abou-Kull; Magdy Amer. "SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW ARYLSULPHONYLUREA AND THIOUREA DERIVATIVES". EKB Journal Management System, 8, 2, 1999, 40-45. doi: 10.21608/zjps.1999.184156
Abou-Kull, M., Amer, M. (1999). 'SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW ARYLSULPHONYLUREA AND THIOUREA DERIVATIVES', EKB Journal Management System, 8(2), pp. 40-45. doi: 10.21608/zjps.1999.184156
Abou-Kull, M., Amer, M. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW ARYLSULPHONYLUREA AND THIOUREA DERIVATIVES. EKB Journal Management System, 1999; 8(2): 40-45. doi: 10.21608/zjps.1999.184156

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW ARYLSULPHONYLUREA AND THIOUREA DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences
Article 6, Volume 8, Issue 2, December 1999, Pages 40-45    PDF (2.59 M)
Document Type: Original Article
DOI: 10.21608/zjps.1999.184156
Authors
Mansour Abou-Kull* 1; Magdy Amer2
1Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt
2Department of Pharmacology, Faculty of Veterinary Medicine, University of Mansoura, Egypt.
Abstract
Certain arylsulphonylureas and thioureas derivatives were synthesized to be tested as hypoglycemic and antimicrobial agents in comparison with glibinclamide and sulphanilamide, respectively. The interaction of 3-chloro-2-p-substitutedphenylamino-N-(4-sulphamoylphenyl) maleimide (2) or its carbamate derivatives (3) with phenylisocyanate, phenylisothiocyanate or with appropriate amine afforded the target products. Some of the new compounds showed considerable hypoglycemic and antimicrobial activities.
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