NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE | ||
Zagazig Journal of Pharmaceutical Sciences | ||
Article 6, Volume 8, Issue 1, June 1999, Pages 47-52 PDF (2.51 M) | ||
Document Type: Original Article | ||
DOI: 10.21608/zjps.1999.184165 | ||
Authors | ||
Mohamed Al-Ashmawi* 1; Lobna Abdel-Aziz2; Samia Mustafa2 | ||
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||
2Department of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig -Egypt. | ||
Abstract | ||
The reaction profile of certain 2-substituted-3-oxo-2,3- dihydrobenzo (d)-1,2- thiazole-1,1-dioxide (N-substitued saccharines) with hydrazine hydrate is described. It was found that the steric hindrance displayed by the substituents at position-2 has a profound effect on reaction rate. Some of the synthesized compounds were subjected to preliminary antimicrobial activity. | ||
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