SYNTHESIS OF SOME NEW 2,4,6-TRISUBSTITUTEDTHIAZOLO-[5,4-d] PYRIMIDINE-5,7(4H,6H)-DIONES.
Basyouni, W., Hosni, H. (1999). SYNTHESIS OF SOME NEW 2,4,6-TRISUBSTITUTEDTHIAZOLO-[5,4-d] PYRIMIDINE-5,7(4H,6H)-DIONES.. EKB Journal Management System, 8(1), 76-81. doi: 10.21608/zjps.1999.184169
Wahid Basyouni; Hanaa Hosni. "SYNTHESIS OF SOME NEW 2,4,6-TRISUBSTITUTEDTHIAZOLO-[5,4-d] PYRIMIDINE-5,7(4H,6H)-DIONES.". EKB Journal Management System, 8, 1, 1999, 76-81. doi: 10.21608/zjps.1999.184169
Basyouni, W., Hosni, H. (1999). 'SYNTHESIS OF SOME NEW 2,4,6-TRISUBSTITUTEDTHIAZOLO-[5,4-d] PYRIMIDINE-5,7(4H,6H)-DIONES.', EKB Journal Management System, 8(1), pp. 76-81. doi: 10.21608/zjps.1999.184169
Basyouni, W., Hosni, H. SYNTHESIS OF SOME NEW 2,4,6-TRISUBSTITUTEDTHIAZOLO-[5,4-d] PYRIMIDINE-5,7(4H,6H)-DIONES.. EKB Journal Management System, 1999; 8(1): 76-81. doi: 10.21608/zjps.1999.184169

SYNTHESIS OF SOME NEW 2,4,6-TRISUBSTITUTEDTHIAZOLO-[5,4-d] PYRIMIDINE-5,7(4H,6H)-DIONES.

Zagazig Journal of Pharmaceutical Sciences
Article 10, Volume 8, Issue 1, June 1999, Page 76-81  XML PDF (2.13 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1999.184169
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Authors
Wahid Basyouni email ; Hanaa Hosni
Pesticide Chemistry Department, National Research Centre, Dokki, Cairo, Egypt.
Abstract
 Reaction of 2,6-disubstitutedthiazolo5,4-dpyrimidin-7(6H)-ones 2 with ethyl chloroformate/ethanol mixture afforded 5-(ethoxycarbonylamino) -2-(substitutedthio) thiazole-4-(N-substituted)-carboxamides 4a-c. Thermal fusion of 4 followed by treatment with dimethyl sulfate gave the corresponding trisubstituted thiazolo[5,4-d]-pyrimidinediones 6. When the thiazole esters 7a,b were reacted with ethyl chloroformate, the corresponding ethyl 5-(ethoxycarbonyl)-aminothiazole-4-carboxylates 8 were Oblained. Reaction of 8b with benzylamine gave the 2-benzylthio-5-(3-benzylureido)thiazole-4-(N-benzyl)carboxamide 9.
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