SYNTHESIS OF SOME NEW 2,4,6-TRISUBSTITUTEDTHIAZOLO-[5,4-d] PYRIMIDINE-5,7(4H,6H)-DIONES. | ||
Zagazig Journal of Pharmaceutical Sciences | ||
Article 10, Volume 8, Issue 1, June 1999, Pages 76-81 PDF (2.13 M) | ||
Document Type: Original Article | ||
DOI: 10.21608/zjps.1999.184169 | ||
Authors | ||
Wahid Basyouni* ; Hanaa Hosni | ||
Pesticide Chemistry Department, National Research Centre, Dokki, Cairo, Egypt. | ||
Abstract | ||
Reaction of 2,6-disubstitutedthiazolo5,4-dpyrimidin-7(6H)-ones 2 with ethyl chloroformate/ethanol mixture afforded 5-(ethoxycarbonylamino) -2-(substitutedthio) thiazole-4-(N-substituted)-carboxamides 4a-c. Thermal fusion of 4 followed by treatment with dimethyl sulfate gave the corresponding trisubstituted thiazolo[5,4-d]-pyrimidinediones 6. When the thiazole esters 7a,b were reacted with ethyl chloroformate, the corresponding ethyl 5-(ethoxycarbonyl)-aminothiazole-4-carboxylates 8 were Oblained. Reaction of 8b with benzylamine gave the 2-benzylthio-5-(3-benzylureido)thiazole-4-(N-benzyl)carboxamide 9. | ||
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