BIOCHEMICAL CHANGES IN SERUM LIPIDS AND LIPOPROTEINS IN Viral C HEPATITIS PATIENTS | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 7, Volume 6, Issue 2, December 1997, Page 35-37 PDF (1.87 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1997.184941 | ||||
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| Author | ||||
Rawia Amin 
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| Biochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. | ||||
| Abstract | ||||
| Serum lipids and lipoproteins were determined in 20 patients with chronic viral C hepatitis as well as 10 volunteers. Liver functions were also performed. Results of the present study showed that there is a significant increase in both total and direct bilirubin (TB & DB). Total proteins and albumin (TP & Alb) showed significant decrease. Liver enzymes; Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) were also significantly increased. Total cholesterol (TC), HDL cholesterol (HDL-C), LDL-cholesterol (LDL-C) and triglycerides (TG) showed significant decrease. Apolipopratein fractions (Apo A1 and Apo B) showed significant decrease. There was a negative correlation between Apo A1, and both TB and ALT. Apo B showed also a negative correlation with TB. This study clarified that patients with hepatitis C virus showed a significant decrease in serum lipids, hence they are less susceptible for atherosclerosis and coronary heart diseases. | ||||
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