SPECTROPHOTOMETRIC DETERMINATION OF QUINIDINE SULFATE BY ION-PAIR FORMATION | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 6, Volume 6, Issue 1, June 1997, Pages 33-40 PDF (3.95 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1997.184952 | ||
| Author | ||
| Mamdouh Metwally* | ||
| Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig- Egypt. | ||
| Abstract | ||
| A simple method for the determination of quinidine sulfate in tablets is based on the formation of an ion-pair between quinidine Comand thymol blue (TB) at pH=5.5 in aqueous-methanol solution. The absorbance of the ion-pair formed is measured and the Colncentration of the drug is calculated. The molar ratio of the ion-pair is determined and found to be 2:1 and with general formula [Q]+4 2.[T.B]-1 SO4-2 HSO4-1 as calculated by elemental analysis. Using the present method quinidine sulfate in tablets was assayed. The results were statistically compared with those obtained by the official method. | ||
|
Statistics Article View: 133 PDF Download: 71 |
||
