EFFECT OF MELATONIN ON BODY TEMPERATURE IN THE RABBITS | ||
| Assiut Veterinary Medical Journal | ||
| Article 30, Volume 31.1, Issue 61, April 1994, Pages 345-355 PDF (4.25 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.1994.185379 | ||
| Authors | ||
| EMTETHAL M. MOSTAFA; IBTISAM M. ELMILIGYDD; M.M. ANWAR | ||
| Abstract | ||
| Intravenous administration of melatonin at doses of M 10 587 0.1-1 mg\kg BW in mature male rabbits decreased the best rectal temperature. The maximum effect, about 0.90 *°C, was reached with the highest dose (1 mg/kg) at 15 min after injection of melatonin. In addition, melatonin antagonized the prostaglandin Fza. (PGF 20)-induced hyp < /strong>erthermia. The hypothermic effect of melatonin in hyperthermic rabbits was more marked than that in animals with normal body temperature. Atropine, hydergine and prop < /strong>ranolol did not antagonize the hypothermic effect of melatonin. It can be concluded that melatonin decreases the body temp < /strong>erature in normal rabbits as well as in rabbits with hyp < /strong>erthermia. These results suggest that the hypothermic effect of melatonin is not mediated through the cholinergic or adrenergic recep < /strong>tors and may be due to its direct relaxant effect on the wall of the blood vessels. Also, melatonin may act centrally through inhibition of PG synthesis and release. | ||
| Keywords | ||
| Melatonin; body temprature and rabbits | ||
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