SYNTHESIS AND SELECTED REACTION OF 9 - (2- CYANOETHYL) -1- OXA- 9 - AZA –TRICYCLO [4.2.1.02,8 ] NONAN- 3 - ONE - 6 - CARBONITRILE
El-Abbady, S., Agamai, S. (1995). SYNTHESIS AND SELECTED REACTION OF 9 - (2- CYANOETHYL) -1- OXA- 9 - AZA –TRICYCLO [4.2.1.02,8 ] NONAN- 3 - ONE - 6 - CARBONITRILE. EKB Journal Management System, 4(2), 62-66. doi: 10.21608/zjps.1995.185629
Samia El-Abbady; Samia Agamai. "SYNTHESIS AND SELECTED REACTION OF 9 - (2- CYANOETHYL) -1- OXA- 9 - AZA –TRICYCLO [4.2.1.02,8 ] NONAN- 3 - ONE - 6 - CARBONITRILE". EKB Journal Management System, 4, 2, 1995, 62-66. doi: 10.21608/zjps.1995.185629
El-Abbady, S., Agamai, S. (1995). 'SYNTHESIS AND SELECTED REACTION OF 9 - (2- CYANOETHYL) -1- OXA- 9 - AZA –TRICYCLO [4.2.1.02,8 ] NONAN- 3 - ONE - 6 - CARBONITRILE', EKB Journal Management System, 4(2), pp. 62-66. doi: 10.21608/zjps.1995.185629
El-Abbady, S., Agamai, S. SYNTHESIS AND SELECTED REACTION OF 9 - (2- CYANOETHYL) -1- OXA- 9 - AZA –TRICYCLO [4.2.1.02,8 ] NONAN- 3 - ONE - 6 - CARBONITRILE. EKB Journal Management System, 1995; 4(2): 62-66. doi: 10.21608/zjps.1995.185629

SYNTHESIS AND SELECTED REACTION OF 9 - (2- CYANOETHYL) -1- OXA- 9 - AZA –TRICYCLO [4.2.1.02,8 ] NONAN- 3 - ONE - 6 - CARBONITRILE

Zagazig Journal of Pharmaceutical Sciences
Article 11, Volume 4, Issue 2, December 1995, Pages 62-66    PDF (2.86 M)
Document Type: Original Article
DOI: 10.21608/zjps.1995.185629
Authors
Samia El-Abbady* 1; Samia Agamai2
1Departments of Chemistry, University College for Girls and Faculty of Engineering , Ain Shams University, Cairo, Egypt.
2Department of chemistry, University college for Girls, Ain Shams University, Heliopolis, Cairo, Egypt.
Abstract
Oxirination of the activated 3,4 -olefinic double bond of 8-(2-cyanoethyl) -8-azabicyclo[ 3.2.1] oct -3-en-2-one -6- carbonitrile (1) with basic hydrogen peroxide afforded 9-(2-cyanethyl)-1-oxa-9-azatricyclo 4.2.1.04,0 nonan-3-one-6-carbonitrile (2). Ring opening of the oxirane ring in (2) has been investigated, using 10% sodium hydroxide, acetic acid, and phenylhydrazine to give (4), (7) and (8) respectively. Structural and configurational assignments were deduced from IR, 'HNMR, UV and mass spectral evidence.
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