SYNTHESIS OF SOME PYRIMIDO-[4', 5' : 4,5]-PYRIMIDO-[ 1,6-a ]INDOLE OF POTENTIAL ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITIES
Ebeid, M., Lashine, S., El-Adl, S., Abou-Kull, M. (1995). SYNTHESIS OF SOME PYRIMIDO-[4', 5' : 4,5]-PYRIMIDO-[ 1,6-a ]INDOLE OF POTENTIAL ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITIES. EKB Journal Management System, 4(1), 36-42. doi: 10.21608/zjps.1995.186326
Mohamed Ebeid; Sayed Lashine; Sobhy El-Adl; Mansour Abou-Kull. "SYNTHESIS OF SOME PYRIMIDO-[4', 5' : 4,5]-PYRIMIDO-[ 1,6-a ]INDOLE OF POTENTIAL ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITIES". EKB Journal Management System, 4, 1, 1995, 36-42. doi: 10.21608/zjps.1995.186326
Ebeid, M., Lashine, S., El-Adl, S., Abou-Kull, M. (1995). 'SYNTHESIS OF SOME PYRIMIDO-[4', 5' : 4,5]-PYRIMIDO-[ 1,6-a ]INDOLE OF POTENTIAL ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITIES', EKB Journal Management System, 4(1), pp. 36-42. doi: 10.21608/zjps.1995.186326
Ebeid, M., Lashine, S., El-Adl, S., Abou-Kull, M. SYNTHESIS OF SOME PYRIMIDO-[4', 5' : 4,5]-PYRIMIDO-[ 1,6-a ]INDOLE OF POTENTIAL ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITIES. EKB Journal Management System, 1995; 4(1): 36-42. doi: 10.21608/zjps.1995.186326

SYNTHESIS OF SOME PYRIMIDO-[4', 5' : 4,5]-PYRIMIDO-[ 1,6-a ]INDOLE OF POTENTIAL ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITIES

Zagazig Journal of Pharmaceutical Sciences
Article 7, Volume 4, Issue 1, June 1995, Pages 36-42    PDF (3.12 M)
Document Type: Original Article
DOI: 10.21608/zjps.1995.186326
Authors
Mohamed Ebeid* 1; Sayed Lashine2; Sobhy El-Adl3; Mansour Abou-Kull4
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt
3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt
4Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt
Abstract
The synthesis of 12,12a-dihydropyrimido-[4',5' : 4,5]-pyrimido-[1,6-a]-indole-1,6[ 2H, 5H]-dione is described. Treatment of enaminonitriles I with chloroacetyl chloride afforded the tetracyclic compounds II. In contrast compound I with nuorophenyl group at position 2 gave N-chloroacetylamino derivatives III which underwent cyclization either by acid or base. Preliminary Pharmacological screening of some compounds showed significant antiinflammatory and antipyretic activities.
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