SYNTHESIS OF NEW NICOTINOYL AMINO ACID DERIVATIVES | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 12, Volume 3, Issue 2, December 1994, Pages 113-118 PDF (2.74 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1994.186485 | ||
| Author | ||
| Atef Amer* | ||
| Chemistry Department, Faculty of Science, University of Zagazig, Egypt. | ||
| Abstract | ||
| (S)-and/or (R)-(2-methyl-3-benzyloxycarbonyl-5-oxo-4-0xazolidinyl)-acetyl chloride, prepared from S-aspartic acid, which was reacted with 3-trimethyl stannylpyridine to give the corresponding pyridyl-ketone, then converted into enantiomeric (S)-and (R)-a- methylnicotinylalanine by hydrolysis with hydrochloric acid. Analogously, a-nicotinylalanine III was prepared from L-glutamic acid. | ||
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