REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY
Al-Ashmawi, M., Meise, W., El-Sayed, A., Lashine, E., Abou-Kull, M. (1994). REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY. EKB Journal Management System, 3(1), 8-19. doi: 10.21608/zjps.1994.186595
Mohamed Al-Ashmawi; Werner Meise; Abdel-Halim El-Sayed; El-Sayed Lashine; Mansour Abou-Kull. "REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY". EKB Journal Management System, 3, 1, 1994, 8-19. doi: 10.21608/zjps.1994.186595
Al-Ashmawi, M., Meise, W., El-Sayed, A., Lashine, E., Abou-Kull, M. (1994). 'REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY', EKB Journal Management System, 3(1), pp. 8-19. doi: 10.21608/zjps.1994.186595
Al-Ashmawi, M., Meise, W., El-Sayed, A., Lashine, E., Abou-Kull, M. REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY. EKB Journal Management System, 1994; 3(1): 8-19. doi: 10.21608/zjps.1994.186595

REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY

Zagazig Journal of Pharmaceutical Sciences
Article 2, Volume 3, Issue 1, June 1994, Pages 8-19    PDF (6.54 M)
Document Type: Original Article
DOI: 10.21608/zjps.1994.186595
Authors
Mohamed Al-Ashmawi* 1; Werner Meise2; Abdel-Halim El-Sayed3; El-Sayed Lashine4; Mansour Abou-Kull5
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Pharmazeutisches Institute der Universitaet Bonn, Kreuzbergweg 26, D-5300 Bonn 1, Germany
3Department of Microbiology, Faculty of Pharmacy, Zagazig University, Egypt
4Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
5Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt
Abstract
The reaction of 2,3-dichloromaleimides 1a-f with binucleophiles, viz, o-aminophenol (2a) and o-phenylenediamine (2b) is described. Products isolated were dependent on both pH and the used reaction solvents. Many of the novel, fused pyrroloquinoxalines and maleimides showed remarkable antimicrobial activities.
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