STEREOSELECTIVE REACTION BETWEEN ACETANTHRANIL AND RACEMIC AMINE | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 5, Volume 3, Issue 1, June 1994, Pages 35-39 PDF (2 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1994.186601 | ||
| Author | ||
| Nabaweya Sharaf El-Din* | ||
| Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tanta, Tanta, Egypt | ||
| Abstract | ||
| Racemic amines 1-phenyl-ethylamine and 1-amino-2-propanol were found to undergo kinetic resolution in the stereoselective reaction with acetanthranil. The residual amines have optical rotation of (+) 5.2° and (+) 4.5° which correspond to optical purity of about 15.7% and 18% for 1-phenylethylamine and 1-amino-2-propanol, respectively. The effect of temperature, reaction time, solvent, concentration of amine and catalyst were examined on the kinetic resolution. | ||
|
Statistics Article View: 94 PDF Download: 135 |
||
